A comparison of the results given in Tables XI. and XII. shows that animals which received lead compounds subcutaneously suffered much more than the animals which received the lead via the gastro-intestinal canal, even when the doses given via the mouth were exceedingly large. It will follow, then, that the actual contact with the more intimate fluids of the body, rather than the digestive juices, determines the solubility and general distribution of the lead compound in the body. This is confirmed by a recent paper by Straub[6]. The animals experimented upon by feeding were kept in the laboratory under the same conditions as the inhalation animals, but were so placed that under no circumstance could they obtain any lead dust by inhalation. These animals were used as control to the breathing experiments, the substance fed to the animals being in all cases the same substance as was used for the various inhalation experiments; but in addition a certain number of the animals were given alcohol, which are referred to in Table XII. Alcohol was also given to animal No. 6 in the inhalation series. The animals fed with lead were fed with the same compound which was used for the inhalation experiments, 0·4 to 1 gramme being given daily; so that during the period these animals were exposed to lead dust the other animals were taking the same compound via the intestinal canal, but in much larger quantities, and yet they exhibited no signs of lead poisoning. TABLE XI.--INOCULATION. +----+-------+---------------------------------------------------+ | No.| | | | of | | | |Ani-| | | |mal.|Weight.|Total Compound used and Quantity. | +----+-------+---------------------------------------------------+ | | Kgs. | | | 16 | 3·200 |0·91 grm. lead acetate: (1) 0·16; (2) 0·5; (3) 0·25| | 25 | 3·350 |Fritted lead: (1) 0·6; (2) 2·0 = 2·6 grms. | | 28 | 3·050 |2 grms. white lead | | 31 | 3·450 |0·35 grm. white lead | | 32 | 2·900 |0·3 grm. frit | | 33 | 3·150 |0·16 grm. PbO as acetate | | 35 | 3·750 |2·0 grms. water-washed frit | | 40 | 3·050 |1·0 grm. unwashed frit | | 41 | 3·000 |1·0 grm. acetic acid and water-washed frit | | 42 | 2·800 |1·0 grm. water-washed frit | | 43 | 2·900 |Lead nitrate in water: 0·01 grm. per diem | +----+-------+---------------------------------------------------+