In the _brain_, as well as in all the tissues, careful search should be made for minute microscopical hæmorrhages, and for evidences of old hæmorrhages in the form of small masses of fibrous tissue, etc. Parenchymatous degeneration, chromatolysis of nuclei, etc., nerve degeneration. The _arteries_ and _veins_ should also receive close scrutiny, as the presence or absence of arteritis should be noted. In the _kidney_ particularly, search should be made for both interstitial and parenchymatous nephritis. The _liver_ frequently shows signs of microscopic hæmorrhage, and it is as well, in taking a portion of tissue for examination, to choose those portions which appear to be specially congested. In the _brain_ and _spinal cord_ and _nervous tissue_, search is to be made for the same hæmorrhages as already noted. In addition, the condition of the nerve fibres should be noted, the presence or absence of periaxial neuritis, as well as degeneration of the axis cells, and the various ganglion cells both in the brain and spinal cord should be closely examined for chromatolysis and nuclear atrophy. No evidence is afforded by micro-chemical tests of any of the sections thus obtained, except those of the lung. It may be possible in the case of the lung to determine the presence of lead granules in the alveolar cells, and attention should be paid to this. It is possible also that some evidence may be afforded by examination microscopically of the red bone-marrow. The intestinal walls should be examined for evidence of lead particles. If any dark staining, deep or superficial, be found in the intestine, it should be removed for chemical analysis. Necrotic areas of the intestinal wall should be sought for. =Hæmatology.=--For all practical purposes, the best stain for detection of basophile granules in the erythrocytes is Wright’s modification of Romanowski’s stain. This stain may be obtained in appropriate tablets, and may be prepared immediately before use, although a stain which has been standing for ten days or a fortnight gives much better results than a quite new stain. The stain consists of a solution of polychrome methylene blue, together with eosin in methyl alcohol, and the method of procedure is as follows: