Lead poisoning and lead absorption : $b The symptoms, pathology and prevention, with special reference to their industrial origin, and an account of the principal processes involving riskLegge, Thomas Morison, Sir
Science
Lead poisoning and lead absorption : $b The symptoms, pathology and prevention, with special reference to their industrial origin, and an account of the principal processes involving risk
Legge, Thomas Morison, Sir
Lead poisoning
An examination of the fæces of persons suspected of lead poisoning
may often give definite results both of the presence of lead and
hæmatoporphyrin. If small hæmorrhages have occurred high up in the
intestine, the presence of hæmatoporphyrin in the fæces may result.
The substance may be easily determined by means of the characteristic
absorption bands. A quantity of fæces is taken and extracted with acid
alcohol, and the filtrate examined spectroscopically. Urobilin bands
are commonly present, and, particularly, where much constipation exists
these bands are very well marked. There is no difficulty whatever,
however, in distinguishing them from the characteristic bands of acid
hæmatoporphyrin.
=Examination of the Fæces for Lead.=--The moist method or chemical
examination given above is the best one to apply for the determination
of lead in the fæces. As has already been pointed out, lead is commonly
excreted in the fæces, and, if only about 2 milligrammes per diem are
being excreted by the fæces in a lead-worker, the quantity cannot be
regarded as indicative of poisoning. One of us (K. W. G.) has at times
found as much as 8 to 10 milligrammes of lead excreted in the fæces of
persons engaged in a lead factory, and exhibiting no signs or symptoms
whatever of lead poisoning. If, however, the quantity of lead in
the fæces rises to anything above 6 milligrammes per diem, there is
definite evidence of an increased absorption of lead, and if at the
same time clinical symptoms be present, suggesting lead poisoning, such
a chemical determination is of the first importance.
In estimating the presence of lead in fæces, it may be necessary
to deal with the separation of iron, which may be precipitated as
phosphate and filtered off, the quantitative estimation being proceeded
with in the filtrate.
Lead is much more commonly present in the fæces of lead-workers than in
the urine, and it is better to examine the fæces rather than the urine
in suspected cases.
REFERENCES.
[1] GAUTIER: Meillère’s Le Saturnisme, p. 74.
[2] MARSDEN AND ABRAM: The Lancet, vol. i., p. 164, 1897.
[3] SHUFFLEBOTHAM AND MELLOR: _Ibid._, vol. ii., p. 746, 1903.
[4] HEBERT: Comptes Rendus, tome cxxxvi., p. 1205, 1903.
[5] FRESENIUS AND VON BABO: Liebig’s Annalen, vol. xlix., p. 287,
1884.
[6] GLAISTER: Medical Jurisprudence and Toxicology. 1910.
[7] DIXON MANN: Forensic Medicine and Toxicology, p. 496.
[8] VERNON HARCOURT, A.: A Method for the Approximate Estimation of
Small Quantities of Lead--Transactions of the Chemical Society, vol.
cxvii., 1910.
[9] KING ALCOCK, S.: Brit. Med. Journ., vol. i., p. 1371, June 24,
1905.
[10] STEINBERG: International Congress Industrial Hygiene. Brussels,
1910.
[11] JOULIE, H.: Urologie Pratique et Thérapeutique Nouvelle.
CHAPTER XI
TREATMENT
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Elsewhere in the archive
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account