Lead poisoning and lead absorption : $b The symptoms, pathology and prevention, with special reference to their industrial origin, and an account of the principal processes involving riskLegge, Thomas Morison, Sir
Science
Lead poisoning and lead absorption : $b The symptoms, pathology and prevention, with special reference to their industrial origin, and an account of the principal processes involving risk
Legge, Thomas Morison, Sir
Lead poisoning
For many years it has been customary in the treatment of men employed
in lead works to give occasional purgatives, and it is, moreover, a
common and proper precaution to keep a stock of some simple aperient
medicine, preferably saline composed of sodium sulphate and magnesium
sulphate, at the works in charge of the foreman, so that any man who
so desires may obtain a dose of an ordinary aperient mixture. We
have seen from the pathological evidence that the largest proportion
of lead is excreted by the bowel, and that, therefore, the sweeping
away of the bowel contents--particularly where constipation is set
up--will naturally tend to remove from the body a good deal of the
lead which has been already excreted into the intestine and which
may presumably become reabsorbed unless it be swept away. In a large
electric accumulator factory Epsom salts in the form of the granular
effervescing preparation is much appreciated. In winter 50 per cent.,
and in summer 90 per cent. of the men are said to take a daily
dose. In an important white-lead works chocolate tablets containing
hypo-(thio-)sulphite of sodium are supplied to the workers.
Another medicine made use of in lead works is the sulphuric acid
lemonade, this being acidulated with sulphuric acid and flavoured
with lemon. It is very questionable whether this substance has any
definite effect in the special direction in which it is supposed to
work--namely, that of forming an insoluble sulphate of lead in the
stomach and so preventing its absorption. The use of this drug was
suggested on the presumption that lead poisoning as a rule took its
origin from the dust swallowed and converted into a soluble form in
the stomach. As we have seen, there is very little evidence that this
entrance of lead is of much importance, although it does occasionally
take place. Furthermore, from the experiments of one of us [K. W.
G.[1]], it has been found that the sulphate of lead is at any rate as
soluble as other lead salts, such as white lead or litharge, when acted
upon by normal gastric juice.
With regard to the drinks supplied to workers in lead factories, it
is highly important that some form of fluid should be supplied which
the men may drink without harm, particularly in the more laborious
forms of employment, and, above all, in the factories where smelting,
desilverizing, etc., of lead is carried on. In these factories
the use of some type of lemonade containing sodium citrate is to
be recommended, as it has been shown that one of the pathological
effects of lead absorption is to produce an increased viscosity of
the blood, and the use of such drugs tends to some extent to diminish
this. A drink containing a few grains of sodium citrate to the ounce
and flavoured with lemon is freely drunk by workmen engaged in the
laborious processes.
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