When treated in the first week or two of the onset, lead paresis frequently recovers, and in a person suffering from lead palsy for the first time, confined only to the hands or to a group of muscles in the shoulder, prognosis is good. The prognosis of palsy of the lower limbs is not so good. Paralysis of the facial nerve is occasionally seen in lead poisoning, and where this occurs it should be treated as previously recommended, by means of iodides in association with localized electrical treatment. One pole of the battery should be placed below the external auditory meatus, and the other one passed over the face on the affected side. In long-standing cases where no attempt has been made at treatment in the early stages of the disease, and where considerable muscle degeneration has already taken place, the prognosis as a rule is very bad. Efforts should always be made in an early case by passive movements and massage of the affected muscles to improve their nutrition as far as possible. The diet should be light, and alcohol should not be given at any time. =Affections of the Central Nervous System.=--The typical form of affection of the central cerebral nervous system caused by lead, is lead encephalopathy. The disease may be insidious in its onset, and may be preceded by a long stage of chronic headache with slight or total remissions. Headaches may last for several months before the actual acute stage of the disease is reached. In the examination of several brains of persons who have died from lead encephalitis, microscopic sections of the brain have shown signs of hæmorrhages which must have taken place some considerable time prior to death, and were no doubt associated with the headache that had been complained of for some time previously, before the onset of the fatal illness. (See Plate III.) Persistent headache occurring in a lead-worker should always be regarded with grave suspicion, and such a case should be treated on the assumption that it is an early case of lead encephalitis. Bromides and iodides should be given, and the patient placed in quiet surroundings, and fed on light, nutritious diet, and every attempt made to produce elimination of the poison. In the acute attacks vaso-motor spasm is no doubt partially accountable for the symptoms, and various dilators, previously noted in discussing colic, may be made use of, such, for instance, as amyl nitrite, scopolamine, etc., whilst pyramidon, antipyrin, phenacetin, and other similar drugs may be given between the attacks. Under no circumstances should any person who has suffered from encephalitis or other cerebral symptom of lead poisoning be allowed to resume work in a lead industry.