The following case of chronic lead encephalitis, with the examination of the nervous system described by Mott[41], is a case that has a large bearing on the general pathology of lead poisoning, and has the merit of being so carefully described that we cite it at length, as bringing out some of the special features connected with the pathology of lead poisoning. The patient was a coach-painter, aged forty-four. Family history of no particular interest. Had been a painter since a boy. No specific history. Treated for enlargement of liver at one time. Married. No children. His wife a widow; four children before married to him. Before the attack of encephalitis, which ultimately resulted in his death, he suffered from colic and obstinate constipation. The commencement of the final attack of lead infection was associated with an epileptiform fit, from which he recovered and resumed his work, but from this time onwards he suffered from progressive weakness and progressive inability to perform his ordinary work. Constant indulgence in alcohol did not pull him together as before; and although previously he had been able to indulge in large quantities of alcohol, a very little now affected him adversely. The first epileptiform attack was in July, and in November he commenced to have delusions, was restless, suspicious. On admission to the asylum he showed marked cachexia. Weight, 8 stone 7 pounds; height, 5 feet 9 inches. There was present well-marked oral sepsis and blue line. _Mental Condition._--Restlessness; disorientation; remitting delirious state; periods of shouting coincident with colic, worse at night; auditory hallucinations. _Physical Condition._--Bilateral wrist-drop; extensor paralysis of the fingers; hand-grip and gait impaired; reaction of degeneration of paralyzed muscles; coarse tremors; fibrillary twitching; staccato articulation. _Sensory._--No definite change. _Reflexes._--Pupils normal. Sluggish reaction to light and accommodation. _Organic._--Deglutition difficult. Micturition and defæcation not under control. _Vaso-motor._--Tâche cérébrale marked. Eye neuro-retinitis. Unequal amaurosis. _Heart._--Increased action, variable; alteration during exacerbations of colic. Second sound in aortic area accentuated. High pressure, variable. Majority of arteries thickened. He suffered gradual mental change; the whole of the mental symptoms increased in severity until the patient looked like the final stages of a case of general paralysis. He died on December 1. Colic was present at intervals during the whole time. Post-mortem made the next day. Septic bronchitis. Hæmorrhage at the base of epiglottis and left vocal cord. _Lungs._--Septic broncho-pneumonia. _Pericardium._--Small amount of fluid. _Heart._--Striated, bluish. Weight 11¹⁄₄ ounces. _Ventricles._--Slight hypertrophy of left ventricle. _Valves._--Competent.