Leprosy : $b in its clinical & pathological aspectsHansen, G. Armauer (Gerhard Armauer)
Science
Leprosy : $b in its clinical & pathological aspects
Hansen, G. Armauer (Gerhard Armauer)
Leprosy
_Koch’s tuberculin_ was administered to five anæsthetic, three
tuberous, and three mixed cases, as a rule, daily, from January 8th to
May 8th. The dose at the commencement was 1 milligramme, and in several
cases as much as 320 milligrammes were finally injected. The injections
were made, sometimes daily, sometimes at intervals of a few days,
according to the degree of reaction which followed the injections.
In some cases the injections had to be stopped very soon, because
they produced fresh leprous eruptions; and in one case bacilli were
found in the blood. It seemed as if the tuberculin had set the bacilli
afloat. We came to the following general conclusions:--(1) Tuberculin
administered to lepers produces a general and local reaction, usually
forty-six hours after the injection, seldom after twelve hours, and
very seldom after two to three days. The local reaction becomes evident
later. (2) These reactions do not beneficially influence the leprosy,
they rather aggravate the disease by causing fresh eruptions just as
iodide does. (3) Tuberculin does not kill the lepra bacillus. (4)
Immunity against tuberculin can be attained, but this immunity does not
influence the progress of leprosy.
Dr. Carreau, in Guadaloupe, treated a leper with _chlorate of
potassium_, he believed with great benefit; he gave the remedy in
enormous doses. Dr. Hjort had, already, in 1838-39 tried this remedy
without effect. Dr. Beaven-Rake has also tried the remedy according to
Dr. Carreau’s directions, but also without result. Dr. Danielssen, too,
tried it, but without any benefit.
During the last few years the following remedies have been tried in
the Lungegaard’s hospital: Hydroxylamin, Europhen, Naphthol, Salol,
Methylene blue, Aristol.
_Hydroxylamin_ forms colourless crystals, easily soluble in alcohol
and glycerine. It is decidedly poisonous, and is, according to some
authors, a more powerful reducing agent than chrysarobin or pyrogallic
acid; 2 to 5 hydroxylamin to 20 glycerine and 80 alcohol, was painted
on the patches of four maculo-anæsthetic lepers. In two of them there
developed, after the painting, an erythema, during the persistence of
which the painting was discontinued. The painting was continued for two
months, and then a 2 per cent. hydroxylamin ointment was applied, but
as no amelioration could be noted after four or five months, the remedy
was laid aside. In four tuberous patients the painting could only be
continued for two or three days, because the spots re-acted severely,
grew red and painful, and vesicles formed. The tubers somewhat
diminished, but otherwise the condition remained unaltered.
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