Various Problems of Alimentation. § 1. _Food the source of Energy and Matter._ The two forms of Energy afforded by Food—Vital Energy, Thermal Energy. Food the source of Heat. The rôle of Heat.—§ 2. _Measure of the output of Energy_—by the Calometric Method—by the Chemical Method.—§ 3. The regular type of Food, Biothermogenic, and the irregular type, Thermogenic.—§ 4. Food considered as the source of Heat. The Law of Surfaces. The limits of Isodynamics.—§ 5. Plastic rôle of Food. Preponderance of Nitrogenous Foods. Among the problems on which energetics has thrown a vivid light we have mentioned alimentation, muscular contraction, and, more general still, the intermittence of vital functional activity. We shall begin with the study of alimentation. _The Different Problems of Alimentation._—What is a food? In what does alimentation consist? The dictionary of the _Académie_ will give us our first answer. It tells us that the word food is applied to “every kind of matter, whatever may be its nature, which habitually serves or may serve for nutrition.” This is very well put, but here again we must know what nutrition is, and that is not a simple matter; in fact, it practically means whatever is usually placed on the table in a civilized and polished society. But it is just the profound reasons for this traditional practice that we are trying to discover. The problem of alimentation may be looked at in a thousand ways. It is culinary, no doubt, and gastronomic; but it is also economical and social, agricultural, fiscal, hygienic, medical, and even moral. But first and foremost, it is physiological. It comprises and assumes the knowledge of the general composition of foods, of their transformations in the digestive apparatus, and their comparative utility in the maintenance and the sound functional activity of the organism. To this first group of subjects for our discussion are attached others relating to the effects of inanition, of insufficient alimentation, and of over-feeding. And in order to throw light on all these aspects of the problem of alimentation, we have to lay bare the most intimate and delicate reactions by which the organism is maintained and recruited, and, in the words of a celebrated physiologist, “to penetrate into the kitchen of vital phenomena.” And here neither Apicius, nor Brillat-Savarin, nor Berchoux, nor the moralists, nor the economists are of any use to us as guides. We must appeal to the scientists, who, following the example of Lavoisier, Berzelius, Regnault, and Liebig, have applied to the study of living beings the resources of general science, and have thus founded _chemical biology_.