I have been deeply interested by your letter, and we had a good laugh over Huxley's remark, which was so deuced clever that you could not recollect it. I cannot quite follow your train of thought, for in the last page you admit all that I wish, having apparently denied all, or thought all mere words in the previous pages of your note; but it may be my muddle. I see clearly that any satisfaction which Pan may give will depend on the constitution of each man's mind. If you have arrived already at any similar conclusion, the whole will of course appear stale to you. I heard yesterday from Wallace, who says (excuse horrid vanity), "I can hardly tell you how much I admire the chapter on 'Pangenesis.' It is a POSITIVE COMFORT to me to have any feasible explanation of a difficulty that has always been haunting me, and I shall never be able to give it up till a better one supplies its place, and that I think hardly possible, etc." Now his foregoing [italicised] words express my sentiments exactly and fully: though perhaps I feel the relief extra strongly from having during many years vainly attempted to form some hypothesis. When you or Huxley say that a single cell of a plant, or the stump of an amputated limb, have the "potentiality" of reproducing the whole--or "diffuse an influence," these words give me no positive idea;--but when it is said that the cells of a plant, or stump, include atoms derived from every other cell of the whole organism and capable of development, I gain a distinct idea. But this idea would not be worth a rush, if it applied to one case alone; but it seems to me to apply to all the forms of reproduction--inheritance--metamorphosis--to the abnormal transposition of organs--to the direct action of the male element on the mother plant, etc. Therefore I fully believe that each cell does ACTUALLY throw off an atom or gemmule of its contents;--but whether or not, this hypothesis serves as a useful connecting link for various grand classes of physiological facts, which at present stand absolutely isolated. I have touched on the doubtful point (alluded to by Huxley) how far atoms derived from the same cell may become developed into different structure accordingly as they are differently nourished; I advanced as illustrations galls and polypoid excrescences... It is a real pleasure to me to write to you on this subject, and I should be delighted if we can understand each other; but you must not let your good nature lead you on. Remember, we always fight tooth and nail. We go to London on Tuesday, first for a week to Queen Anne Street, and afterwards to Miss Wedgwood's, in Regent's Park, and stay the whole month, which, as my gardener truly says, is a "terrible thing" for my experiments. CHARLES DARWIN TO W. OGLE. (Dr. William Ogle, now the Superintendent of Statistics to the Registrar-General.) Down, March 6 [1868]. Dear Sir,