He felt that every hour was precious. In Rome, he found the Pantheon "simple and grand"; the Apollo Belvidere "the most perfect of human productions," while the Venus de Medici has "the excellence of feminine form, destitute in a great measure of intellectual expression"; the "Transfiguration," "beautiful in color and chiaroscuro," and Michael Angelo's "Moses," "one of the things never to be forgotten." On his return to New York he took rooms at the corner of Wall Street and Broadway. Here he won the friendship of Luman Reed, for whom he promised to paint pictures for one room, to cost five thousand dollars. The chief pictures for Mr. Reed, who died before their completion, were five, called "The Course of Empire," representing man in the different phases of savage life, high civilization, and ruin through sin, the idea coming to him while in Rome. Of this group, Cooper, the novelist, said, "I consider the 'Course of Empire' the work of the highest genius this country has ever produced, and one of the noblest works of art that has ever been wrought." In November, 1836, Mr. Cole was married to Maria Bartow, a young lady of refinement and loveliness of character. Soon after, both of his parents died. The "Departure and Return" were now painted, "among his noblest works," says Bryant, followed by the "Voyage of Life," for Mr. Samuel Ward, who, like Mr. Reed, died before the set was finished. This series was sold in 1876 for three thousand one hundred dollars. These pictures he had worked upon with great care and intensity. He used to say, "Genius has but one wing, and, unless sustained on the other side by the well-regulated wing of assiduity, will quickly fall to the ground. The artist must work always; his eye and mind can work even when his pen is idle. He must, like a magician, draw a circle round him, and exclude all intrusive spirits. And above all, if he would attain that serene atmosphere of mind in which float the highest conceptions of the soul in which the sublimest works have been produced, he must be possessed of a holy and reasonable faith." The "Voyage of Life" was well received. The engraver, Mr. Smilie, found one morning before the second of the series, "Youth," a person in middle life looking as though in deep thought. "Sir," he said at length, "I am a stranger in the city, and in great trouble of mind. But the sight of these pictures has done me great good. I go away from this place quieted, and much strengthened to do my duty."