The application of the principle in human affairs is rendered uncertain by the immense complication of the phenomena, the difficulty of experiment, and the special liability of our judgments to prejudice. That men and communities of men are influenced by circumstances is not to be denied, and the influence of circumstances, if it is to be traced at all, must be traced through observed facts. Observation of the succession of phenomena must be part at least of any method of tracing cause and effect. We must watch what follows upon the addition of new agencies to a previously existing sum. But we can seldom or never get a decisive observation from one pair of instances, a clear case of difference of result preceded by a single difference in the antecedents. The simple Method of Experimental Addition or Subtraction is practically inapplicable. We can do nothing with a man analogous to putting him into a hermetically sealed retort. Any man or any community that is the subject of our observations must be under manifold influences. Each of them probably works some fraction of the total change observable, but how are they to be disentangled? Consider, for example, how impossible it would be to prove in an individual case, on the strict principle of Single Difference, that Evil communications corrupt good manners. Moral deterioration may be observed following upon the introduction of an evil companion, but how can we make sure that no other degrading influence has operated, and that no original depravity has developed itself in the interval? Yet such propositions of moral causation can be proved from experience with reasonable probability. Only it must be by more extended observations than the strict Method of Difference takes into account. The method is to observe repeated coincidences between evil companionship and moral deterioration, and to account for this in accordance with still wider observations of the interaction of human personalities.