With regard to the preparation of vaccines, and the ascertaining of their proper strength, it is necessary to make trials upon a certain number of fowls, even at the risk of sacrificing a few in these preliminary experiments. Beyond such questions of manipulation there remains still a scientific question. How are the effects of vaccination to be conceived? What explanation can be given of the fact that a benign disease can preserve from a more serious and deadly one? Pasteur long sought for the solution of this problem. Without flattering himself that he has unravelled the difficulty, he has nevertheless amassed facts which, amid these physiological mysteries, permit us to frame a hypothesis which can satisfy the mind. Pasteur believes, for example, that the vaccine, when cultivated in the body of the animal, robs the globules of the blood, for example, of certain material principles which the vital actions take a long time to restore to the system, and which to the most deadly contagium is a condition of life. The impossibility of action of the progressive virus and of the deadly virus is thus accounted for. When Pasteur communicated to the Academy of Sciences these important and unforeseen facts, they were at first received with hesitation. It was not without some surprise that the word vaccination, hitherto exclusively reserved for Jenner's discovery, was heard applied to fowl cholera. At the International Medical Congress held in London in August 1881, Pasteur, in the presence of 3,000 doctors of medicine from all parts of the world, who received him with an enthusiasm which reflected glory on France, justified the name that he had given to his prophylactic experiments. 'I have lent,' he said, 'to the expression vaccination an extension that I hope science will consecrate, as a homage to the merit and immense services rendered to humanity by one of the greatest men of England--Jenner.'