In the epidemic which ravaged the silkworm nurseries in 1849 the symptoms were numerous and changeable. Sometimes the disease exhibited itself immediately. Many of the eggs were sterile, or the worms died during the first days of their existence. Often the hatching was excellent, and the worms arrived at their first moulting, but that moulting was a failure. A great number of the worms, taking little nourishment at each repast, remained smaller than the others, having a rather shining appearance and a blackish tint. Instead of all the worms going through the phases of this first moulting together, as is usually the case in a batch of silkworms, they began to present a marked inequality, which displayed itself more and more at each successive moulting. Instead of the worms swarming on the tables, as if their number was uniformly augmenting, empty spaces were everywhere seen; every morning corpses were collected on the litters. Sometimes the disease manifested itself under still more painful circumstances. The batch would progress favourably to the third, and even to the fourth moulting, the uniform size and the health of the worms leaving nothing to be desired; but after the fourth moulting the alarm of the husbandman began. The worms did not turn white, they retained a rusty tint, their appetite diminished, they even turned away from the leaves which were offered to them. Spots appeared on their bodies, black bruises irregularly scattered over the head, the rings, the false feet, and the spur. Here and there dead worms were to be seen. On lifting the litter, numbers of corpses would be found. Every batch attacked was a lost batch. In 1850 and 1851 there were renewed failures. Some cultivators, discouraged, attributed these accidents to bad eggs, and got their supplies from abroad. At first everything went as well as could be wished. The year 1853, in which many of these eggs were reared in France, was one of the most productive of the century. As many as twenty-six millions of kilogrammes of cocoons were collected, which produced a revenue of 130,000,000 francs. But the year following, when the eggs produced by the moths of these fine crops of foreign origin were tried, a singular degeneracy was immediately recognised. The eggs were of no more value than the French eggs. It was in fact a struggle with an epidemic. How was it to be arrested? Would it be always necessary to have recourse to foreign seed? and what if the epidemic spread into Italy, Spain, and the other silk cultivating countries?