In preparing both the first and later editions of this little work (that has brought happiness to so many by opening the way to knowledge of a proper means of cure and methods of regaining health and vigor), +the utmost care and circumspection have been exercised in an endeavor to exclude from its pages anything that could be construed by the most fastidious as immodest, obscene, or in any way offensive to decency, morality or good breeding+. Indeed, although purely and essentially +a medical work, and intended solely for such persons whose duty it is to be acquainted with the facts given+, in order to understand their complaint, to place themselves under proper treatment, and to avoid the dangers of quackery, we have in many instances wholly excluded or materially modified the wording of passages in order to comply with our original ideas of the strictest purity of thought and speech commensurate with a truthful and honest statement of facts. We wish it distinctly understood that +this treatise is intended solely for persons suffering from Genito-Urinary Diseases+, and that it is +never mailed to any person who has not voluntarily requested us to send it+, and then +not to boys+ or to members of the +opposite sex+. (Our application books show a large number of such refusals.) We look upon our special mission in the field of medicine as +distinct+, +laudable+ and +holy+. There are those who look down upon this special branch of medicine, and some ignoramuses who assert that such diseases only exist in the imaginations of such patients as a result of reading the pamphlets of quacks who paint frightful pictures of insanity, idiocy, etc. To such men as these we have only this to say: Consult the works of Hammond, Black, Acton, Wilson, Lallemand, Civiale, Courtenay, Lee etc., etc., the authors of which have world-wide reputations, not only as physicians, but as truthful, honest and moral men. They will then see how really grave are such affections and how needful of aid. God knows that the misery, despondency and actual organic disease, as a result of early vices, are prevalent enough even to-day to make a lover of his fellow men sincerely pity and desire to help them. And we claim (and every honest man cannot but admit) that it is only by the +widespread dissemination of a knowledge of certain facts+ to young and old, especially the former, that such vice and its consequences can be met and overcome. We are daily spreading such knowledge throughout the length and breadth of this land, not only warning and advising the young and cautioning the older, but also pointing out to all such as need it a perfect and easy means of cure and restoration to health and vigor.