Labrusca is indigenous to the eastern part of North America, including the region between the Atlantic Ocean and the Alleghany Mountains. It is sometimes found in the valleys and along the western slopes of the Alleghanies. Many botanists say it never occurs in the Mississippi Valley. In the first-named area it ranges from Maine to Georgia. It has the most restricted habitat of any American species of horticultural importance, being much exceeded in extent of territory by _V. rotundifolia_, _V. aestivalis_ and _V. vulpina_. Labrusca has furnished more cultivated varieties, either pure-breeds or hybrids, than all other American species together. The reason for this is partly, no doubt, that it is native to the portion of the United States first settled and is the most common grape in the region where agriculture first advanced to the condition at which fruits were desired. This does not wholly account for its prominence, however, which must be sought elsewhere. In its wild state, Labrusca is probably the most attractive to the eye of any of our American grapes on account of the size of its fruit, and this undoubtedly turned the attention of those who were early interested in the possibilities of American grape-growing to this species rather than to any other. The southern Labrusca is quite different from the northern form and demands different conditions for its successful growth; in the North, at least two types of the species may be distinguished. Vines are found in the woods of New England which resemble Concord very closely in both vine and fruit, excepting that the grapes are much smaller in size and more seedy. There is also the large-fruited, foxy Labrusca, usually with reddish berries, represented by such cultivated varieties as Northern Muscadine, Dracut Amber, Lutie and others. Labrusca is peculiar amongst American grapes in showing black-, white- and red-fruited forms of wild vines growing in the woods. Because of this variability, it is impossible to give the exact climatic and soil conditions best adapted to the species. It is reasonable to suppose, however, that the ideal conditions for this species under cultivation are not widely different from those prevailing where the species is indigenous. In the case of Labrusca, this means that it is best adapted to humid climates, and that the temperature desired varies according to whether the variety comes from the southern or northern form of the species.