SYMPTOMS.—After a period of incubation, lasting from three to six days, the animal is seized with a shivering fit, and appears dull and stupified. A vesicular eruption soon appears on the mouth, the hoofs, and the teats. Suckling lambs, have a similar eruption on the mouth and throat, with irritation of the whole alimentary canal, attended with inability to suck, and exhausting diarrhea. The eyes are then observed to be dim, watery, congested; the muzzle, ears and horns alternately hot and cold; shivering ensues; rumination is diminished; the milk is less in quantity, yellower and thicker than usual, and much deteriorated in quality; the bag swollen, tender, hot; the back arched; the coat staring and harsh; the pulse somewhat accelerated; the temperature moderately elevated, reaching 102°, or even 104°; the eruption in the mouth is first seen on the inner surface of the upper lip, the edge of the upper jaw where there are no teeth, on the tip and edges of the tongue, and is indicated by salivation, by pain and loss of power in taking and eating food. The vesicles occur on the mucous membrane, singly or in patches, first as little red spots, then as whitish-yellow, slightly turbid blisters, about the size of a bean, at first transparent, but subsequently filled with a puriform fluid. These vesicles burst in about eighteen hours, discharge their fluid, leaving behind shallow ulcers, which often run together and then form deep and ragged ulcers. The lips, cheeks, tongue, and sometimes the Schneiderian membrane, are affected. The eruption on the feet is first seen around the coronet and in the interdigital space, especially of the hind legs; and the resulting vesicles burst quickly, because of the animal’s movements. The animal evidently suffers intense pain, is lame or unable to stand, and moves reluctantly or cautiously; the hoofs swell; the vascular secreting membranes become inflamed; the hoofs are cast; the bones may become diseased; and serious mischief may ensue. The eruption on the udder turns to vesicles, as in the mouth, and, when the fluid dries or escapes, thin scales are formed. The teats are swollen and sore. In exceptional cases, a vesicular eruption appears on the muzzle, the mucous membrane of the nostrils, the conjuctivae of the eyes, and the mucous membrane of the vagina. In favorable cases, the fever subsides about the fourth day, the eruption declines, the appetite returns, and in seven to fourteen days the animal recovers. But complications are not uncommon. And in unfavorable cases the fever is high, the ulceration increases, the animal suffers from exhaustion, wasting, discharge of stringy, bloody mucous from the mouth, and of offensive matter from the nostrils; the face is swollen, the breath foul, the respiration rapid and grunting; the pulse small, weak, rapid; the blood becomes impure; the belly and legs œdematous; the hoofs slough off; diarrhea supervenes, and death follows about the ninth or tenth day.