The eruption on the feet is first seen around the coronet and in the interdigital space, especially of the hind legs; and the resulting vesicles burst quickly, because of the animal’s movements. The animal evidently suffers intense pain, is lame or unable to stand, and moves reluctantly or cautiously; the hoofs swell; the vascular secreting membranes become inflamed; the hoofs are cast; the bones may become diseased; and serious mischief may ensue. The eruption on the udder turns to vesicles, as in the mouth, and, when the fluid dries or escapes, thin scales are formed. The teats are swollen and sore. In exceptional cases, a vesicular eruption appears on the muzzle, the mucous membrane of the nostrils, the conjunctivae of the eyes, and the mucous membrane of the vagina. In favorable cases, the fever subsides about the fourth day, the eruption declines, the appetite returns, and in seven to fourteen days the animal recovers. But complications are not uncommon. And in unfavorable cases the fever is high, the ulceration increases, the animal suffers from exhaustion, wasting, discharge of stringy, bloody mucous from the mouth, and of offensive matter from the nostrils; the face is swollen, the breath foul, the respiration rapid and grunting; the pulse small, weak, rapid; the blood becomes impure; the belly and legs œdematous; the hoofs slough off; diarrhea supervenes, and death follows about the ninth or tenth day. An aggravation may occur in milch cows by the bursting of the vesicles when the teat is grasped in milking, for the fluid escapes, the sore bleeds and ulcer spreads; and though the sore be scabbed over between the milking times, the scab is then again pulled off. The consequence is that the cow, feeling intense pain and irritation, kicks, resents the milking, holds back the milk, and thus prevents the “stripping” of the udder. The effect of this may be an attack of inflammation of the udder, which may prove fatal, or may be followed by induration and atrophy of the udder. Or abscesses may form in the udder, and sometimes large portions of it slough away, rendering the cow comparatively useless for milking purposes. Abortion is not uncommon. This disease may be easily mistaken for Stomatitis, cow pox or fowl of the foot. However in Stomatitis there is no eruption on the foot; and in cow pox and fowl of the foot there is no eruption on the muzzle. PROGNOSIS.—This is unfavorable—The United States Government and the Health Officers of the several States require all suspected cases of Foot and Mouth Disease to be quarantined, and upon the full development of the disease all animals infected, to be killed. Human beings are liable to become infected, great care should be exercised in handling diseased animals or their carcases. Rheumatism This disease is almost invariably the consequence of cold and wet, or chill after over-exertion. The symptoms are as follows: