In the spring of 1876, she went to Ohio on the occasion of a reunion of the first five graduating classes of the W. F. Seminary, Oxford, Ohio. She desired with great desire to meet her class-mates, and the beloved principal, Miss Helen Peabody; and also to visit relatives, among them two aged aunts, one of whom crossed over to the other side a little before her. She took great delight in her visit, and yet her nights were wearisome, and she was probably not entirely comfortable at any time. But she did not complain. On her last visit home her face bore the impress of great suffering. It was with difficulty she could raise either hand to her head, and could only sleep with her arms supported on pillows. They would fain have kept her at home, but she longed to do what she could as long as she could. So she went back, taught in the school, visited the sick, read from the Bible in the tents, and prayed. In her last illness some of these women came and prayed with her, and so comforted her greatly. She did not forget her brother's children, in her anxiety for the heathen around them, and they will long remember Aunt Nannie's prayerful instructions. With so little strength as she had, it was not strange that, when fever prostrated her, she could not rally again. So she lay for nearly eight weeks, suffering much, but trusting much also. At times she hoped to be able to work again for the women, if the Lord willed. But when she knew that her earthly life was nearly ended, she sent this message to her aunt: "Do not grieve, dear aunt, Though I had desired to do much for these women and girls, the prospect of heaven is very sweet." For a while she had said now and then: "I wonder how long I shall have to lie here and wait," but one day she remarked, "I do not feel at all troubled now about how long I may have to wait: Jesus has taken that all away." When any one came in to see her, she said a few words, and as the school children were gathered around her one day she talked to them a little while for the last time. Two days before her death, she dictated a letter to her father, who had himself been very near death's door, but was recovering: "I do rejoice that God has restored you to health again. I trust that years of usefulness and happiness may still be yours. I am gaining both in appetite and strength. I feel a good deal better." But the night that followed was a sleepless one, and the next day she suffered greatly. About dark her brother said to her, "You have suffered a great deal to-day." She answered, "Yes, but the worst is over now." He said, "Jesus will send for you," and she replied, "Yes, I think he will, for he says, 'I will that they also, whom thou hast given me, be with me where I am.'"