I. Wounds on different parts of the body are the most frequent causes of this disease. It was formerly supposed it was the effect only of a wound, which partially divided a tendon, or a nerve; but we now know it is often the consequence of læsions which affect the body in a superficial manner. The following is a list of such wounds and læsions as have been known to induce the disease: 1. Wounds in the soles of the feet, in the palms of the hands, and under the nails, by means of nails or splinters of wood. 2. Amputations, and fractures of limbs. 3. Gun-shot wounds. 4. Venesection. 5. The extraction of a tooth, and the insertion of new teeth. 6. The extirpation of a schirrous. 7. Castration. 8. A wound on the tongue. 9. The injury which is done to the feet by frost. 10. The injury which is sometimes done to one of the toes, by stumping it (as it is called) in walking. 11. Cutting a nail too closely. Also, 12. Cutting a corn too closely. 13. Wearing a shoe so tight as to abrade the skin of one of the toes. 14. A wound, not more than an eighth part of an inch, upon the forehead. 15. The stroke of a whip upon the arm, which only broke the skin. 16. Walking too soon upon a broken limb. 17. The sting of a wasp upon the glands penis. 18. A fish bone sticking in the throat. 19. Cutting the navel string in new-born infants. Between the time in which the body is thus wounded or injured, and the time in which the disease makes its appearance, there is an interval which extends from one day to six weeks. In the person who injured his toe by stumping it in walking, the disease appeared the next day. The trifling wound on the forehead which I have mentioned, produced both tetanus and death, the day after it was received. I have known two instances of tetanus, from running nails in the feet, which did not appear until six weeks afterwards. In most of the cases of this disease from wounds which I have seen, there was a total absence of pain and inflammation, or but very moderate degrees of them, and in some of them the wounds had entirely healed, before any of the symptoms of the disease had made their appearance. Wounds and læsions are most apt to produce tetanus, after the long continued application of heat to the body; hence its greater frequency, from these causes, in warm than in cold climates, and in warm than in cold weather, in northern countries.