The efficacy of these remedies will probably be disputed by every regular-bred physician, who has not been a witness of their utility in the above disease; but it becomes such physicians, before they decide upon this subject, to remember, that many things are true in medicine, as well as in other branches of philosophy, which are very improbable. In all those cases of _autumnal_ intermittents, whether quotidian, tertian, or quartan, in which the bark did not succeed after three or four days trial, I have seldom found it fail after the application of blisters to the wrists. But in those cases where blisters had been neglected, or applied without effect, and where the disease had been protracted into the _winter_ months, I have generally cured it by means of one or two moderate bleedings. The pulse in those cases is generally full, and sometimes a little hard, and the blood when drawn for the most part appears sizy. The bark is seldom necessary to prevent the return of the disease. It is always ineffectual, where blood-letting is indicated. I have known several instances where pounds of that medicine have been taken without effect, in which the loss of ten or twelve ounces of blood has immediately cured the disease. I once intended to have added to this account of the efficacy of blisters and bleeding in curing obstinate intermittents, testimonies from a number of medical gentlemen, of the success with which they have used them; but these vouchers have become so numerous, that they would swell this essay far beyond the limits I wish to prescribe to it. AN ACCOUNT OF THE DISEASE OCCASIONED BY _DRINKING COLD WATER_ IN WARM WEATHER, AND THE METHOD OF CURING IT. Few summers elapse in Philadelphia, in which there are not instances of many persons being diseased by drinking cold water. In some seasons, four or five persons have died suddenly from this cause, in one day. This mortality falls chiefly upon the labouring part of the community, who seek to allay their thirst by drinking the water from the pumps in the streets, and who are too impatient, or too ignorant, to use the necessary precautions for preventing its morbid or deadly effects upon them. These accidents seldom happen, except when the mercury rises above 85° in Fahrenheit's thermometer. Three circumstances generally concur to produce disease or death, from drinking cold water. 1. The patient is extremely warm. 2. The water is extremely cold. And 3. A large quantity of it is suddenly taken into the body. The danger from drinking the cold water is always in proportion to the degrees of combination which occur in the three circumstances that have been mentioned.