2. _Symptoms of the second degree._ In this case where the patient lives two or three days, or perhaps longer, as in the case of _William Mitchell_ above described (p. 190), the earliest symptoms are heat and thirst, or vomiting, and inexpressible uneasiness and anxiety, the former of which is less frequently observed than the two latter; purging, or sometimes a repeated but ineffectual desire to go to stool; wandering pains; quick, but feeble pulse; head-ache; distended and painful abdomen; priapism; towards the close of the scene the patient often becomes more tranquil and is inclined to sleep, although, in some instances, the pains, attended with convulsions, continue to the latest moments. In general, death takes place suddenly. In cases where the effects of the poison are not immediately fatal, we must necessarily expect the occurrence of many phenomena, indicative of the re-action of the system, and which will be better illustrated by a reference to the history of individual cases, such for instance, as those of _William Mitchell_, (p. 190) and _Mr. Blandy_, (_Appendix_) than by any general description which can be given in this place. It is also worthy remark that in such cases, from the length of time, there will necessarily occur a greater opportunity for the co-operation of other contingent causes, whether they be connected with previously existing diseases, or the action of remedies; and the intelligent practitioner will not neglect to appreciate their influence in modifying the character of each particular case. There are besides symptoms highly characteristic when they do arise, but which are of comparatively rare occurrence, such as the ulcerated condition of the fundament, as in the case of _Mr. Blandy_, and the inflamed eyes and state of the mucous membranes, in that of _William Mitchell_.