The real reason then, it would seem, why syphilis came to be called the _morbus Gallicus_, or French Disease, was because when knowledge of its differential diagnosis was generalized, physicians at the same time learned of the remedy which could be so successfully employed for its treatment, the value of which had been determined as the result of the careful observations of the surgeons of South France. It is probable, as I have said, that the original idea for this form of treatment came from the Italian surgical traditions brought over from Italy by Lanfranc and his contemporaries at the end of the thirteenth century. There can be no doubt at all, however, of the power of clinical observation of the medieval surgeons who gave us this wonderful advance in therapeutics. The most distinguished pupil of Guy de Chauliac was Pietro d'Argelata, who died about 1423 as a professor at Bologna, but whose textbook, "The Cirurgia," was among the first of medical books to be printed at Venice in 1480. His teaching was still a living force at that time, and it is evident that he had attracted wide attention in his own generation. He taught the dry treatment of wounds, suggesting various powders to be employed on them, and gave his experience with sutures and drainage tubes in wounds. Ligatures are often supposed to have been invented much later. They have been attributed to Ambroise Paré and other surgeons of the Renaissance period, but were probably used at many times during the Middle Ages, and had been invented and frequently employed by the Greeks. They invariably went out of use after a time, however, and had to be reinvented. As I said in "Old-Time Makers of Medicine": "It is hard to understand how so useful an auxiliary to the surgeon as the ligature--it seems indispensable to us--could possibly be allowed to go out of use and even be forgotten. It will not be difficult, however, for anyone who recalls the conditions that obtained in old-time surgery to understand the succession of events. The ligature is a most satisfying immediate resource in stopping bleeding from an artery, but a septic ligature inevitably causes suppuration, and almost inevitably leads to secondary hæmorrhage. In the old days of septic surgery, secondary hæmorrhage was the surgeon's greatest and most dreaded bane. Some time from the fifth to the ninth day a septic ligature came away under conditions such that inflammatory disturbance had prevented sealing of the vessel. If the vessel was large, the hæmorrhage was fast and furious, and the patient died in a few minutes. After a surgeon had had a few deaths of this kind he dreaded the ligature.