In all that Abernethy had hitherto published, it was easy to perceive that, although he was carefully examining the prevailing opinions and practice of the day, he was emphatically one of those independent thinkers who had power to overlay the most established conventionalisms with opinions of his own. Although hitherto his publications had related to particular diseases or accidents which were held as within the ordinary province of the surgeon, he was shadowing forth _principles_—views which, if they were true, must necessarily have a much wider range of application than to the particular cases which it had been his object to consider. In 1804, he had sufficiently matured his general views to think it right to publish them; and this he did in his book on the "Constitutional Origin of Local Diseases," popularly known as the "My Book," to which he not unfrequently referred his patients for a more detailed account of his views, than he could find time to give in the consulting room. When we reflect that diseases consist entirely of altered conditions in the structure or function of some part of the body, a formal announcement that they must be greatly influenced by the organs on which _the whole body depends_ for its nutrition, seems to have so much the aspect of an obvious truism, that we scarcely know whether most to wonder at so formal an announcement of it having been necessary, or the astonishing number and variety of the reservations with which it has been admitted. But, strange as this may appear, and although all the facts have been before the eyes of man for ages—nay, though their relations have been _more or less felt_ and acknowledged in cases usually submitted to the physician,—we venture to say that nothing like an attention at all adequate to their importance was obtained for them in the practice of physic, and scarcely any at all in surgery, _until the time of Abernethy_. At the present time, a great deal has been done to establish, by the most clear and indisputable demonstration, the practical usefulness and necessity of the principles to which Abernethy conducted us, in the cure of diseases, whether medical or surgical. Still, these principles are much neglected, much misunderstood, or so _imperfectly carried out_, as to excite, even in many of the public, expressions of astonishment. It is, indeed, not too much to assert, that, even in those cases in which their successful application has been most incontestibly exemplified, his principles are _fully carried out on comparatively few occasions_. The causes of all this are, we fear, too easily detected; the removal of them is indeed sufficiently difficult. We may possibly discuss both points in the sequel.