I could bring together numerous separate accounts of the fatal ravages of this disease among the Indians in different portions of the continent. Bernal Dias, _incidentally_ mentions, that it carried off a _million_ shortly after the conquest, but how many more we are not told. The disease, no doubt, appeared at different intervals. A sermon by a New England divine, (in the collection of Mr. Force) of 1621, mentions that not more than one in twenty of the natives then remained, the rest having been carried off by the small-pox. In a Jesuit account which I found in the same collection, it appears that it broke out among the Indians in Chiwawa in 1617, and carried off whole tribes of Indians. There was no escape from it, for as long as two remained together the contagion might be there; it was, therefore, more fatal than an atmospheric epidemic, which might be checked by change of place or season. The Indian fled from his village or town, and never returned to it; he never dared to approach it afterwards, believing it to be haunted by evil spirits. In many places, this superstitious dread prevails to this day. McKenzie gives the following account of the destruction of the Knistenew and Chippowyen tribes in 1780: “This was the small pox which spread its destructive and desolating power, as the fire consumes the dry grass of the field. The fatal infection spread round with a baneful rapidity which no flight could escape, and with a fatal effect that nothing could resist. It destroyed with its pestilential breath whole families and tribes; and the horrid scene presented to those who had the melancholy and afflicting opportunity of beholding it, a combination of the dead, the dying, and such, as to avoid the horrid fate their friends around them, prepared to disappoint the plague of its prey, by terminating their own existence. “The habits and lives of those devoted people, which provided not to-day for the wants of to-morrow, must have heightened the pains of such an affliction, by leaving them not only without remedy; but even without alleviation. Nought was left to those but to submit in agony and despair.”