He injected little doses of the sheep serum into guinea-pigs; the
next day he pumped virulent diphtheria bacilli into these same
beasts. It was marvelous to watch them. There they were, scampering
about with never a sign of sickness, while their companions (who had
got no protecting dose of serum) perished miserably in a couple of
days. How good it was to see them die, those unguarded beasts! For
it was these creatures told him how well the serum saved the other
ones. Hundreds of pretty experiments of this kind Behring made (there
was little sloppiness now) and his helpers maybe pointed to their
foreheads, asking whether their chief would ever have done saving one
set of guinea-pigs and killing another set to prove he had saved the
first. But Behring had reasons. “We made so many experiments because
we wanted to show Herr Koch how far we had come in our immunizing of
laboratory animals,” he wrote in one of his early reports.
There was only one fly in the ointment of his success--the guarding
action of the antitoxin serum didn’t last long. For a few days after
guinea-pigs had got their injections of serum they stood big doses of
the poison, but presently, in a week or two weeks, it took less and
less of the toxin to kill them. Behring pulled at his beard: “This
isn’t practical,” he muttered, “you couldn’t go around giving all the
children of Germany a shot of sheep serum every few weeks!” And alas,
his eagerness for something to make the authorities wide-eyed, led
him away from his fine fussings with a way to prevent diphtheria--it
sent him a-whoring after the pound of cure....
“Iodine tri-chloride is almost as bad for guinea-pigs as the microbes
are--but this antitoxin serum, it doesn’t give them sores and
ulcers.... I know it won’t hurt my animals.... I know it kills poison
... now, if it would cure!”
Carefully he shot fatal doses of diphtheria bacilli into a lot
of guinea-pigs. Next day, they were seedy. The second day their
breath came anxiously. They stayed on their backs with that fatal
laziness.... Then Behring took half of this lot of dying beasts, and
into their bellies he injected a good heavy dose of the antitoxin
from his immune sheep. Miracles! Nearly every one of them (but not
all) began to breathe more easily in a little while. Next day, when
he put them on their backs, they hopped nimbly back to their feet.
They stayed there. By the fourth day they were as good as new, while
their untreated companions, cold, dead, were being carried out by the
animal boy.... The serum cured!
Public-domain text, read in full here on John Shaqi.
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