The great medical congresses of those brave days were exciting
debating societies about microbes, about immunity, and it was in
the weeks before a congress (Metchnikoff always went to them) that
his laboratory buzzed with an infernal rushing to and fro. “We must
hurry,” Metchnikoff exclaimed, “to make all of the experiments
necessary to support my arguments!” The crowd of adoring assistants
then slept two hours less each night; Metchnikoff rolled up his
sleeves, too, and seized a syringe. Young rhinoceros beetles, green
frogs, alligators, or weird Mexican axolotls were brought from the
animal house by the sweating helpers (sometimes the ponds were
dredged for perch and gudgeon). Then the mad philosopher, his eyes
alight, his broad face so red that it glowed like some smoldering
brush-fire under his beard, his mustaches full of bacilli spattered
into it by his excited and poetic gestures--this Metchnikoff, I say,
proceeded to inject swarms of microbes into one or another of his
uncomplaining, cold-blooded menagerie. “I multiply experiments to
support my theory of phagocytes!” he was wont to say.
VI
It is amazing, when you remember that his brain was always inventing
stories about nature, how often these stories turned out to be true
when they were put to the test of experiment. A German hunter had
claimed: “There is nothing to Metchnikoff’s theory of phagocytes.
Everybody knows that you can see microbes inside of phagocytes--they
have undoubtedly been gobbled up by the phagocytes. But these
wandering cells are not defenders, they are mere scavengers--they
will only swallow dead microbes!” The London Congress of 1891 was
drawing near; Metchnikoff shouted for some guinea-pigs, vaccinated
them with some cholera-like bacilli that his old friend, the
unfortunate Gamaléia, had discovered. Then, a week or so later, the
big-bearded philosopher shot some of these living, dangerous bacilli
into the bellies of vaccinated beasts. Every few minutes, during the
next hours, he ran slender glass tubes into their abdomens, sucked
out a few drops of the fluid there, and put it before the more or
less dirty lens of his microscope, to see whether the phagocytes of
the immune beasts were eating up Gamaléia’s bacilli. Presto! These
roundish crawling cells were crammed full of the microbes!
“Now I shall prove that these microbes inside the phagocytes are
still alive!” cried Metchnikoff. He killed the guinea-pig, slashed it
open, and sucked into another little glass tube some of the grayish
slime of wandering cells which had gathered in the creature’s belly
to make meals off the microbes. In a little while--for they are
very delicate when you try to keep them alive outside the body--the
phagocytes had died, burst open, and the _live_ bacilli they had
swallowed galloped out of them! Promptly, when Metchnikoff injected
them, these microbes that had been swallowed, murdered guinea-pigs
who were not immune.
Public-domain text, read in full here on John Shaqi.
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