It was about the early part of the year 1652 that the calamity was consummated. At the age of forty-three he was in total darkness. The deprivation of sight, one of the severest afflictions of which humanity is capable, falls more heavily on the man whose occupation lies among books, than upon others. He who has most to lose, loses most. To most persons books are but an amusement, an interlude between the hours of serious occupation. The scholar is he who has found the key to knowledge, and knows his way about in the world of printed books. To find this key, to learn the map of this country, requires a long apprenticeship. This is a point few men can hope to reach much before the age of forty. Milton had attained it only to find fruition snatched from him. He had barely time to spell one line in the book of wisdom, before, like the wizard's volume in romance, it was hopelessly closed against him for ever. Any human being is shut out by loss of sight from accustomed pleasures, the scholar is shut out from knowledge. Shut out at forty-three, when his great work was not even begun! He consoles himself with the fancy that in his pamphlet, the _Defensio_, he had done a great work (_quanta maxima quivi_) for his country. This poor delusion helped him doubtless to support his calamity. He could not foresee that, in less than ten years, the great work would he totally annihilated, his pamphlet would he merged in the obsolete mass of civil war tracts, and the _Defensio_, on which he had expended his last year of eyesight, only mentioned because it had been written by the author of _Paradise Lost_. The nature of Milton's disease is not ascertainable from the account he has given of it. In the well-known passage of _Paradise Lost_, iii. 25, he hesitates between amaurosis (drop serene) and cataract (suffusion) So thick a drop serene hath quench'd their orbs, Or dim suffusion veil'd. A medical friend referred to by Professor Alfred Stern, tells him that some of the symptoms are more like glaucoma. Milton himself has left such an account as a patient ignorant of the anatomy of the organ could give. It throws no light on the nature of the malady. But it is characteristic of Milton that even his affliction does not destroy his solicitude about his personal appearance. The taunts of his enemies about "the lack-lustre eye, guttering with prevalent rheum" did not pass unfelt. In his _Second Defence_ Milton informs the world that his eyes "are externally uninjured. They shine with an unclouded light, just like the eyes of one whose vision is perfect. This is the only point in which I am, against my will, a hypocrite." The vindication appears again in Sonnet xix. "These eyes, though clear To outward view of blemish or of spot." In later years, when the exordium of Book iii. of _Paradise Lost_ was composed, in the pathetic story of his blindness, this little touch of vanity has disappeared, as incompatible with the solemn dignity of the occasion.