There are, however, other signs which are more to be depended on than these that have been mentioned. Females _cease to be regular during pregnancy_. A healthy married woman, during the period of child-bearing, bases her prediction upon this sign, and is seldom disappointed. But women are not all healthy; disease and disorder of the womb, or other organs of the body, especially of the lungs, may cause suppression of the catamenia; and, on the other hand, the discharge may recur for several months after conception, or even monthly during the period of utero gestation; and, in anomalous cases, some young married women, who had hitherto been quite regular, ceased to menstruate for several months without any known cause. _Morning sickness_ is one of the earliest signs of pregnancy, as it often occurs within two weeks. The nausea may be slight or it may be very distressing; it may happen to be soon relieved, but it usually continues for three or four months or longer. It varies also as regards the time of day during which it continues to be bad; but if it recurs at the regular time and in the regular manner, it is of great value as an evidence of pregnancy, when combined with other symptoms. _A dark brown areola_ around the nipple may usually be noticed at the end of the second month; this is a distinguishing sign, especially if it be a first pregnancy. A month or two later, the dark color is more obvious, and it is darker in persons with dark hair, etc. It may be described as being a dark circle, somewhat swollen, or with a puffy turgescence, both of the nipple and the surrounding disk; the surface of the areola studded over and rendered unequal by the prominence of the glandular follicles, the integument covering the part soft and moist; sometimes small mottled patches, of a whitish color, scattered over the outer surface of the areola, and for about an inch all around it. These marks are quite plain at the fifth month, and at six months a number of silvery _streaks_ may be observed.