CHRONIC INTERSTITIAL NEPHRITIS. (Sclerosis or Cirrhosis of the Kidneys. Granular, Contracted or Gouty Kidney).--This is met with, (a) as a sequence of the large white kidneys forming the so-called pale granular or secondary contracted kidney; (b) as an independent primary affection; as a sequence of arterio-sclerosis. Causes.--The primary form is chronic from the onset, and is a slow creeping degeneration of the kidney substance, and in many respects an anticipation of the gradual changes which take place in the organ in extreme old age. Families in which the arteries tend to degenerate early are more prone to this disease. Doctor Osler says: "Among the better classes in this country Bright's disease is very common and is caused more frequently by over-eating than by excesses in alcohol." Arterio-Sclerotic Form.--This is the most common form in this country, and is secondary to arterio-sclerosis. The kidneys are not much, if at all, contracted; very hard, red and show patches of surface atrophy. It is seen in men over forty who have worked hard, eaten freely, and taken alcohol to excess. They are conspicuous victims of the "strenuous life," the incessant tension of which is felt first in the arteries. After forty, in men of this class, nothing is more salutary than to experience the shock brought on by the knowledge of albumin and cast tubes in the urine. Symptoms.--Perhaps a majority of the cases are latent (hidden) and are not recognized until the occurrence of one of the serious and fatal complications. There may have been no symptoms to suggest to the patient the existence of a dangerous malady. In other cases the general health is disturbed. The patient is tired, sleepless; he must get up two or three times at night to pass urine; the digestion is disordered, the tongue is coated; the patient complains of a headache, failing sight, and gets out of breath by exercising. There may be vomiting, headache, neuralgia, and increase of the quantity of urine is common. This is light in color, of low specific gravity, 1005 to 1012; frequently there is a trace of albumin and a few casts of the hyaline and granular kind. In the late stages the albumin may be increased with high specific gravity and a less quantity of urine. The disease often lasts for a year. In the arterio-sclerotic variety the urine may be normal or diminished in quantity, specific gravity normal or increased, the casts are more numerous, and the albumin is usually more abundant. There is an enlargement of the heart; the pulse is increased in tension; the wall of the artery is thickened. The skin is usually dry, with eczema common, but dropsy is rare, except when it is due to heart failure. There may be bronchial and lung troubles; attacks of uraemia, or hard breathing caused by the heart, frequently occurs. There may be hemorrhage of the brain or hemorrhage of the membranes, and these are often fatal. [160 MOTHERS' REMEDIES]