1. There is a group of cases showing the laboratory signs characteristic of central nervous system syphilis: (_a_) positive W. R. in the serum, (_b_) positive W. R. in the spinal fluid, (_c_) pleocytosis, (_d_) excess of albumin, and (_e_) of globulin in the spinal fluid, (_f_) gold sol reaction of central nervous system syphilis, and which show no sign or symptom of neurosyphilis. 2. We believe these cases represent a form of chronic cerebrospinal syphilis, probably paretic in type. 3. They have the greatest theoretical and practical significance in the consideration of the life history of neural syphilis, in the concept of _Allergie_, in regard to results of treatment, and finally as to the evaluation of the laboratory tests. 4. Here is perhaps offered the last link to form a complete chain between the symptoms of the primary stage of syphilis and its final termination of life as the result of the diseases cerebrospinal syphilis or general paresis. =SYPHILIS (?); EXOPHTHALMIC GOITRE; neurosyphilitic old lesion of optic thalamus; unilateral induration and atrophy of left cerebral cortex. Autopsy.= =Case 53.= Carrie Pearson, a housewife 25 years of age, died at Danvers Hospital less than a week after admission, and it was at first stated that her symptoms had lasted but two weeks before admission. In point of fact, a further investigation showed an important succession of symptoms, lasting some four years. Carrie had been considered a healthy child, going to school at the usual age, and progressing well with her studies. She however, left school in the ninth grammar grade, at the age of 15, and went to work in a milltown. She married a worthless person at the age of 18, and lived with her husband for three years. There was one child born a year after marriage. Two years later, however, a tremendous goitre had developed such that her neck was described as “out square with the face,” and at the same time the patient’s eyes had become prominent. About two weeks before admission, she had gone to a neighboring town to take care of a sick woman, but during her endeavor to be a nurse, she had broken out into a mania, tearing up furniture and bedding, and talking irrelevantly for a period of four days. She also showed insomnia and continually tore off her clothing from her body.