Slight tricuspid endocarditis. Bicuspid aortic valve. Hypostatic pneumonia. Acute and chronic splenitis. Fatty liver (central necroses?). Acute nephritis. Chronic gastritis. Small breasts. Axillary hair absent. Petechial eruption of chest. Varicose veins. Chronic external adhesive pachymeningitis of left side. Moderate swelling of right hemisphere with venous injection. Slight occipital gliosis of both sides. Slight gliosis of orbital and hippocampal gyri of right side. Sclerosis with atrophy of occipital and hippocampal white matter of right side. Gliotic lesion (1.5 × 2 × 2 cm. of right lenticular nucleus involving anterior commissure). 1. Was the exophthalmic goitre in Carrie Pearson due to syphilis? Unfortunately we have no clear proof that Carrie Pearson was syphilitic. She was stated to have been syphilitic by the physician who treated her before her commitment to Danvers Hospital. There is, however, no proof of syphilis, inasmuch as the patient died in the pre-Wassermann period. 2. Is the thalamic lesion probably syphilitic? No lymphocytosis or plasmocytosis characterizes the lesion, which is the only lesion of the sort in the Danvers collection. It would not do to call a lesion syphilitic just because it is _sui generis_. In any event, the clinical analysis of the case faced the claim of syphilis as an actual factor in the patient’s life and as a possible factor in the goitre. =It is well known that the ARGYLL-ROBERTSON PUPIL is characteristic of the so-called “PARA-SYPHILITIC DISEASES” (“general paresis” and “tabes”); does this sign occur in other neurosyphilitic conditions?= =Case 54.= Julius Kantor was a shoemaker of 35 years, who came to the hospital for treatment because his family physician had found a positive W. R. in Kantor’s blood serum. He had had a cough for a number of years, and during the last year a little blood had been found in the sputum; whereupon Kantor had been placed under active anti-tuberculosis treatment. The enterprising family physician had found the positive W. R. in the first days of his treatment for tuberculosis. There was, in fact, a history of a chancre nine years before, which had not been followed by any secondary or tertiary symptoms, and which had been but scantily treated. There were no mental symptoms. Kantor was =physically= fairly well developed and nourished. There were a few piping râles in the left upper chest, both in front and back, and also a slight dulness with increased vocal and tactile fremitus. No tubercle bacilli, however, could be found on repeated sputum examination.