Neurosyphilis : $b Modern systematic diagnosis and treatment presented in one hundred and thirty-seven case historiesSouthard, Elmer Ernest
Science
Neurosyphilis : $b Modern systematic diagnosis and treatment presented in one hundred and thirty-seven case histories
Southard, Elmer Ernest
Neurosyphilis
We found the W. R. of the serum to be appropriately positive. The W. R.
of the spinal fluid was also positive though weakly so. There was an
excess of albumin; globulin appeared in large amount; the gold sol
reaction was of the syphilitic type; there were 186 cells in the spinal
fluid.
Is this case one of paresis or of some other form of cerebrospinal
syphilis? Let us consider the data of the =physical examination=. On the
whole, the patient was well preserved. There was a slight radial
arteriosclerosis, but on the whole the cardiovascular system was almost
negative. The blood pressure was 100 systolic, 65 diastolic.
=Neurologically= the visual field of the left eye was somewhat limited,
and there was a temporal hemianopsia of the right eye. The
ophthalmoscopic examination showed a disseminated choroiditis on both
sides. The right pupil failed to react to light. The left pupil reacted
slowly. Both pupils reacted properly to accommodation.
The knee-jerks could be obtained only on reinforcement, and when
obtained, the right was apparently more active than the left. The left
Achilles was absent; the right present. There were no other abnormal
reflexes.
The motility of the facial muscles was somewhat impaired.
Finger-to-finger and finger-to-nose tests were rather poorly done. The
muscle sense was good; there was no swaying in Romberg position; and
there was no speech defect.
We are unable to decide whether the case is one of the =parenchymatous=
type (paretic) or of the =meningovascular= type of =neurosyphilis=. It
is certainly rather unusual to find hemianopsia in a paretic.
We have been unable to get definite results from the treatment of this
case, since the patient would not return for months after getting an
injection or two of salvarsan, on the ground that he was improved enough
and did not require further treatment.
1. What conclusion can be drawn from the 186 cells per cmm. in the
spinal fluid? Ordinarily this finding would indicate an active
process. Some writers have claimed that a cell count running above
100 per cmm. was an indicator of diffuse non-paretic
neurosyphilis. It does not appear that this claim has been
substantiated. It is remarkable that this case shows an interval
of 40 years between infection and the occurrence of definite
clinical symptoms. With respect to the cell count, both in
untreated and in treated cases, the following conclusions from a
recent article (Solomon and Koefod)[14] are in point:
1. The number of cells found in the fluid of untreated cases
offers no definite information of prognostic value.
2. One is not justified in drawing any conclusions as to whether
the case is cerebrospinal syphilis or general paresis, nor the
time the process has been active, nor the severity of it, from the
cell count.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Elsewhere in the archive
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account