=NEUROSYPHILIS with total duration of symptoms twenty-two days. The comparatively MILD BRAIN LESIONS, INFLAMMATORY AND NOT DEGENERATIVE in type, suggest the possibility that therapy might have been successful. Autopsy.= =Case 100.= Jacob Methuen, 35, was a carpenter from Newfoundland. He was working upon a certain Thursday with his brother, who noticed that Jacob was lifting the tools about in an unusual manner and talking strangely to his fellow workmen. He fell asleep, going home in the street car, and said afterward that he felt dazed and peculiar. He talked all kinds of nonsense to his wife upon arrival. Methuen remained in bed next day, fancying he was going to die, calling his family together, and saying good-bye to them. He remained in bed all through the next day, but on Sunday appeared better,—more active, and in fact quite natural. He slept only an hour Sunday night, calling to his wife that it was time to get up. On Monday he began to be irritable to his wife, and accused her of flirting with his brother and intending to elope with him. He struck his wife several times, and when two brothers came to watch him, accused them both of trying to steal his wife, and struck them. Tuesday he remained in bed until late at night, when he arose and tried to assault the family. It seems that another brother of the patient had died but eleven days before his admission to the hospital and five days before the onset of Jacob’s symptoms. Since his brother’s death he had been dwelling upon religious matters, and in fact the day after his brother’s death, he waked up during the night, saying that he was too happy to sleep, that he heard the Master’s voice, and at times the devil’s voice; that there was to be a modern miracle and his spiritual life from now on would be different. Eleven days after admission to the hospital, Methuen died, making a total duration of symptoms, beginning at his brother’s death, of 22 days. =NEUROSYPHILITIC LESIONS= =LESIONS OF THE SECONDARY PERIOD= (1) INTERSTITIAL ENCEPHALITIS OR MYELITIS (“meningitis”) (2) PARENCHYMATOUS ENCEPHALITIS OR MYELITIS (“encephalitis,” “myelitis”) =LESIONS OF THE TERTIARY PERIOD= (1) CHRONIC INTERSTITIAL ENCEPHALITIS OR MYELITIS (“gummatous meningitis”) (2) CHRONIC PARENCHYMATOUS ENCEPHALITIS (“dementia paralytica”) (3) CHRONIC PARENCHYMATOUS MYELITIS (“tabes dorsalis”)