There is, perhaps, no well proven remedy in the Materia Medica, of equal value to that of which I present a brief study, that has been so wholly overlooked by the homoeopathic profession. There certainly is none which possesses a more marked individuality, and which more fully fills a place by itself. It is safe to say that not one in ten of those who practice the healing art has ever used it or is familiar with its pathogenesis. Having not unfrequently cured cases with it, which had refused to yield to other remedies apparently well indicated, I have come to regard it as among the important drugs in our super-abundant Materia Medica. Its effects upon mental conditions are marked by depression of spirits, irritability, inability to study, or to remember what has been read, bringing to our minds _Aconite_, _Bryonia_, _Chamomilla_, _Coffea_, _Colocynth_, _Ignatia_, _Lachesis_, _Mercury_, _Nux vomica_, _Staphisagria_, _Stramonium_, and _Veratrum_. Its effects upon the head are deep-seated and persistent. There is vertigo, confusion, severe pain in many parts of head, with upward pressure described as of a bursting character. The pain may be in forehead, back of eyes, through temporal region on either side, but always of a pressive or bursting nature. For congestive headaches it is as valuable as _Belladonna_, _Glonoine_, _Nux vomica_, or _Sepia_. In and about the eyes there is itching, smarting, swelling, heat and soreness; the itching being especially marked and usually regarded as characteristic. The last named symptom is no less prominent in affections of the ears, as has often been shown in the efficacy of buckwheat flour in frost-bites, or erysipelas of those useful organs, from time immemorial. Here the similarity to _Agaricus_ will readily be recognized. The nose does not escape. It is swollen, red, inflamed and sore. There is at first fluent coryza with sneezing, followed by fulness, dryness and the formation of crusts. Nor is the burning absent which has been elsewhere noted. There is much soreness and somewhat persistent pain from even gentle pressure. The face is pale or unevenly flushed, with dark semi-circles below the eyes. Later, the face becomes swollen, hot and dry, as though severely sunburnt, and the lips are cracked and sore. The mouth feels dry and hot, and yet saliva is not wanting. There is soreness and swelling of roof of mouth, and the tongue is red and fissured along its edges. The bad taste in the morning reminds us of _Pulsatilla_.