No. 4. Since my article on neuralgia I had a quite severe case of sciatica that had taxed the skill of one of my worthy competitors for nearly two months without any good results; he was about to go to Hot Springs for some relief. Meeting me on the street, wanted to know if I thought any of my "little pills or drops would give any relief." I assured him that I was quite positive that I could. He could hardly move about, and suffered very much if he did; he came and got a prescription and found relief to his great astonishment almost immediately; has had it refilled twice and has worked every day; he takes the remedy morning and night; there is no pain or soreness, nor has there been any after first day, only if he sneezes or gets the leg cramped there seems to be slight contraction of nerve, but the remedy has done most satisfactory work in this case and gained a valuable family. I hope these few cases may be of some benefit to the readers of the _Recorder_: 1. Be careful to observe the rule that if remedy should nauseate cease giving for twelve or twenty-four hours. 2. Always give on sugar or in tablets. 3. Remove it immediately from room after administering. 4. Cover joints to exclude air and keep them warm. 5. Give any other indicated remedy. HELODERMA HORRIDUS. PREPARATION.--The virus, obtained by irritating the animal and allowing it to bite on glass, is triturated in the usual way. (Dr. T. L. Bradford furnishes us with the following classification of this reptile): The heloderma is classed as follows: Order: Saurii. Lacertilia. Lizards. Sub order: 5. Fissilinguia. Family: Lacratidæ. Heloderma horridum of Mexico; the crust lizard; the Mexican Caltetopen. Called heloderma from its skin being studded with nail or tubercle-like heads. The Gila monster is a native of Arizona, New Mexico and Texas. It is smaller than the Mexican variety, and is called, by Cope, Heloderma Suspectum. It is the only lizard whose character is not above reproach, hence the name. Zoology says: An esquamate-tongued lizard with clavicles not dilated proximally, a postorbital arch, no postfront-osquamosal arch, the pre and post frontals in contact, separating the frontal from the orbit, and furrowed teeth receiving the different ducts of highly developed salivary glands. (There has been considerable difference of opinion as to whether the Heloderma is poisonous or not; but the following abstract from a paper on the subject read before the College of Physicians, Philadelphia, 1883, by S. Wier Mitchell, together with the provings made later, ought to very effectually settle all dispute on this point; the conclusions are the result of experiments on animals): The poison of heloderma causes no local injury. It arrests the heart in diastole, the organ afterwards contracts slowly--possibly in rapid rigor mortis.