_Upper Extremities._--Numbness of right arm and hand with trembling. Tingling in arms and hands. Tingling in palm of left hand and along fingers. Drawing in left hand, followed by tingling and prickling. Pains in hands, if holding anything for some time. Trembling of hands. Hands blue, cracked and rough. _Lower Extremities._--Numb feeling around and down left thigh. Pain in left thigh and calf as if bruised. Numb feeling down right leg. Coldness extending from knee to calf. Coldness of legs and feet. Boring sharp pain on tibia of right leg. Sensation of tight hand around left ankle. Trembling of limbs. Jerking of limbs. Tingling and burning of feet as if recovering from being frozen. Burning in feet, preventing sleep, had to put them out of bed. Sensation as if walking on sponge and as if swollen. Staggering gait. Tendency to turn to right when walking. When walking lift feet higher than usual and put down heel hard. _Skin._--Itching of skin as from insects. _Sleep._--Drowsiness, but inability to sleep. Restless sleep; awakens at 3 A.M. Awakened from sleep by jerking in head; trembling of limbs; pain in lumbar muscles. _Fever._--Internal coldness. Severe chill ran down back. Cold rings around body. Cold waves ascend from feet, or downward from base of brain. _Nerves._--Startled easily. Trembling. Tired feeling; very weak and nervous. Intense aching in bones and all parts of body. Trembling of left side; hands shaky. Trembling can be controlled by effort of will. _Generalities._--Stretching relieves pains in muscles and limbs. Stitch pains going from left to right. Weak, giddy, making it difficult to stand. Unable to balance myself. Movement does not increase the pain. Throbbing all over body. Bone pains. JACARANDA GUALANDAI. NAT. ORD., Bignoniaceæ. COMMON NAME, Carroba. PREPARATION.--The dried leaves are crushed and macerated in five parts by weight of alcohol. (Of this South American remedy the _Dispensatory_ says it is used in Brazil and other South American countries for syphilis; sometimes under the name _Carroba_. Its value was also asserted in _British Medical Journal_, 1885. The following letter from Dr. J. F. Convers, of Bogota, to Messrs. Boericke & Tafel, throws some further light on its use; the letter is dated November 24, 1888): _Dear Gentlemen_: Please to accept the leaves of a tree of the Bignoniacea family, called _Jacaranda gualandai_, that I send you with this, because it is very much used by our natives to cure illness of a syphilitic character. I have used the mother tincture (5 drops _pro dosi_), and the 3d dilution of it, in the treatment of blennorrhagia and chancroids with the greatest success. In my experience I have found that this medicine is a complementary and antidote to _Merc. v._ Mr. José M. Reyes, who proved the [Greek: theta] and the 2x dilution during more than one month three times a day, found the following results: