In regard to the sexual organs we quote from that racy writer, Dr. S. A. Jones, who says: "_Onosmodium Virginianum_ in its primary action seems directly opposite to _Picric acid_. Perhaps provings of it with smaller doses will oblige me to change this _dictum_. If they do not, then _Onosmodium_ will occupy the singular position of a remedy that _primarily depresses the sexual appetite_. If this should ultimately prove to be the case, it will invest this remedy with an unmistakable significance to physicians who are practicing at the _tail end_ of the nineteenth century, for, from our habits of life, it is the _end_ that is showing signs of distress. In estimating the validity of this suggestion, the reader will bear in mind Hahnemann's _dictum_ that _only the primary symptoms of a drug afford the indications for its therapeutical application_. This is a canon of Hahnemannian Homoeopathy, and it _is true as regards the infinitesimal dose_. Then, this being true (for I will not stop to discuss it), _Picric acid_ will be indicated for the _initial stage_ of sexual debility and _Onosmodium_ for the _fully developed consequences_ of sexual abuse; and this, because the said 'initial stage' is characterized by erethism while the ulterior consequences are denoted by atony asthenia. The erethism of sexual debility is plainly evinced in _Picric acid_, and the ultimate asthenia is as really discovered in _Onosmodium Virginianum_." In the male we find diminished sexual desire. Cold feeling in the glans penis. Nocturnal emissions. Too speedy emissions. Deficient erections with diminished pleasure. In the female we find SEVERE UTERINE PAINS. BEARING-DOWN PAINS IN THE UTERINE REGION. Uterine cramps. _Soreness in region of uterus_, increased by _pressure_ of the hand or of the clothing; had to remove the corset. Return of old uterine pains. Dull, heavy aching, and slowly pulsating pains in the ovaries. Pains pass from one ovary to the other and leave a soreness which remains till the pain returns. Ovarian pains increased by pressure. SEXUAL DESIRE COMPLETELY DESTROYED. This symptom I have verified a number of times, and in every case the parties prevented conception. The uterine pains are all better when undressed or lying on the back. Constant feeling as though the menses would appear. Menses early and profuse, but otherwise normal so far as known. Leucorrhoea light yellowish, slightly offensive and excoriating; profuse, running down the legs. Itching of the vulva aggravated by scratching and from the leucorrhoeal discharge. Aching in both breasts, but worse in the left. Breasts feel swollen and engorged. Left breast feels bruised and painful on pressure. Nipples itch. In one case where this remedy was given for dryness of the nose and throat, the diminutive almost absent, breasts were restored to their pristine glory, and resulted in the displacement of the cotton batting pads to the exceeding joy and delight of the proud woman.