It is a perennial plant, with herbaceous or slightly shrubby stems, the foliage remaining green during winter when grass is scarce, and so attracting animals that would otherwise probably instinctively shun it. The plants do not appear to be equally poisonous at all seasons or in all localities, and it has been doubted whether the active properties they possess are due to a normal constituent of the plant. No medical use has ever been made of these plants, although their poisonous character has often led to the suggestion that they might be found valuable. No physiological study has been made of the action of the poison, and no complete chemical analysis has as yet appeared. The stockmen speak of it as causing intoxication in the animals which eat it, and a prominent symptom is the "loco" condition, in which the power of co-ordination is lost or greatly limited. They cannot readily readjust for changes in gait, etc. A horse travels on level ground, but finds great difficulty in changing to pass over an elevation or depression, or, when going up hill, he has great difficulty in starting down hill; it is difficult, when he is still, to impress him that he must go, and as difficult to stop him when desired. The same rule applies to eating and other necessaries. Such a horse is said to be "locoed." Professor Hawkes procured specimens from which Boericke & Tafel made a tincture. To further test the merits of the remedy, the students of the class at Hahnemann Medical College of Chicago kindly participated in a proving. Professor Hawkes received some reports from his group, but has mislaid his papers, and he is unable to give in detail the symptoms produced. He stated, however, that the principal action corroborated that given above. During 1886-'87 term I made another attempt, and a few reports were received. The remedy was given by number, that the prover should not know what he took, nor the strength of it. Some were given the [Greek: theta], others 1x^d, 2x^d, 3x^d, 12x powders, 30x powders, and some higher. A few reported "no effect" from the [Greek: theta]. The following includes the report from five persons: 1. (Mr. S. P. F., 10 drops of [Greek: theta].) 2. (Mrs. W., 10 drops of 3x^d repeated.) 3. (Mr. G. H. A., 15 drops of 3x^d.) 4. (Mrs. P., powders of 12x repeated.) 5. (Mrs. L., powders of 30x.) 6. (Mrs. L., powders of 12x.) SYMPTOMATOLOGY. _Mind._--Great mental depression,^1,^3. Cannot think or concentrate his thoughts,^1,^3. Very forgetful of familiar words and names,^3. No life,^1. Disinclination to talk or study,^3. Wants to be alone,^3. Is better satisfied to sit down and do nothing,^3. Feels perfectly despondent,^3. A feeling as if I would lose consciousness,^3. All symptoms worse when thinking of them,^1,^3. _Sensorium._--Strange sensation about the head,^4. A feeling as if I would lose consciousness, or as if I would fall when standing,^5. Sense of fulness of the head, and of instability, when standing or sitting,^6.