CASE IV.--"A man 45 years of age, _of delicate constitution, poorly nourished, with a straw yellow face, yellow sclerotics, enlarged liver and spleen, the latter somewhat painful to pressure_, who had contracted _intermittent fever_ while in Panama, and had taken quinine, was complaining, when Dr. Ramirez Tovar saw him (middle part of December), _of a pain in the right side_ (more severe in some points than in others), which commenced at 1 P.M., with _shiverings_, and which disappeared after two hours to return again the next day at precisely the same time and with the same symptoms. He received 1 gram of _Parthenina_, in 5 doses, one every hour, right after the cessation of the pain. He was seen by the doctor the next day at 4 P.M., and up to that time the pain had not returned. He took then 50 centigrams more, in 5 doses, one every hour, and was free of pain until the latter part of January, when he again consulted the doctor, this time the _pain being located in the stomach_, for which _Parthenina_ was repeated (1 gram in 5 doses, one every two hours). The next day the pain had ceased, but returned on the third, and he again received 1 gram, in the same manner as before, and since then he has been free from pain." CASE V.--"A young lady, 18 years of age, complained of _facial neuralgia with periodical exacerbations_, from which she was suffering four days. She received 1 gram of _Parthenina_, in 5 doses, one every hour, and on the following day she was entirely free from pain. Fifty centigrams more, in 4 doses, were given to this lady to prevent a relapse, and the result was a complete cure." And to finish this report, I will mention a case which came under my notice: "A little girl, my niece, 5 years old, living in Havana, who, when seen by the late Dr. Govantes, of that city, had been suffering for some time before from _a continued fever, with periodical mid-day exacerbations, which later on, assumed an intermittent type_. She had been saturated with _quinine_, and complained, at the time, of _malaise_, _lassitude_, _languor_, _headache_, _loss of appetite_, _gastric intolerance_, _etc._ The temperature went up as high as 40.6° C. during the hot stage, which was short and was followed by copious sweats, giving relief. _Parthenium hysterophorus_ in the form of an extract, prepared and sold at Dr. Villavicenci's Pharmacy, in Havana, was prescribed by Dr. Govantes. Three doses a day, each of the size of a pea, dissolved in water, were given for 4 or 5 days, and at the end of that time she was entirely free of fever and made a quick recovery." If such results can be ascribed to _Parthenium_ and its alkaloid _Parthenina_, I think it would be unjustifiable to set them aside. An early proving of the plant will not only enhance our therapeutic resources, but prevent the non-scrupulous from employing it empirically. * * * * * Proving of _Parthenium hysterophorus_, Dr. B. H. B. Sleght.