Numerous articles have appeared in our medical journals during the past few months relative to the treatment of persons bitten by venomous reptiles, especially the rattlesnake. Whether the rattlesnakes found in the marshes of Indiana are in any respect different from those found in Oregon, or in the mountains of Pennsylvania, I do not know. The bite of the Indiana rattler has been known to prove fatal to both man and beast. Notwithstanding we have growing in our woods and fields a small plant, which I believe to be a specific for the treatment of persons or animals bitten by the rattlesnake. From my own experience and observation in the use of this remedy, I believe it to be a positive cure in all cases if exhibited in any reasonable time. I have never known it to fail in a single instance, even where the alcoholic treatment and many other kinds had failed. The plant referred to, the roots of which are used in the treatment of snake bites; or a tincture made from the roots, is the _Sisyrinchium_ of the _Iris_ family, I think, and is said to have been used by the Indians in treating snake bites, by bruising and moistening the roots and applying to the wound. I am not aware of its ever having been used as a medicine by the profession, and, so far as I know, I am the first to prepare and use it in the form of a tincture. By your kind permission I will report, through the columns of your valuable journal, a few cases treated by this remedy, which for convenience I will call _Sisyrinchium_.