Dr. Gillespie, of Edinburgh, "cured an obstinate intermittent with cobweb after other means had failed." Dr. Robert Jackson was led from this to try it himself. He told his success to Dr. Chapman, of Philadelphia, who requested one of his pupils, Dr. Broughton, to investigate the subject, which he did, and wrote his Inaugural Thesis thereon in 1818. From these and other authorities we can gather enough testimony to show that it is well worth while to make a systematic proving of this animal product, thereby predicating its sphere and precisioning its employment. In a work on fevers--which particular edition I have not been able to consult--Dr. Jackson writes: "I think I may venture to say that it prevents the recurrence of febrile paroxysms more abruptly, and more effectually, than bark or arsenic, or any other remedy employed for that purpose with which I am acquainted: that, like all other remedies of the kind, it is only effectual as applied under a certain condition of habit; _but that the condition of susceptibility for cobweb is at the same time of more latitude than for any other of the known remedies_." If we bear in mind Grauvogl's constitution-classification of _Diadema aranea_ as an hydrogenoid remedy, and recall how generally the hydrogenoid constitution is induced by intermittent fever, we shall be ready to acknowledge the truth of the passage which I have placed in italics, and with this evidence of a truthful beginning we shall be more ready to accept the subsequent testimony. "If the cobweb," continues Dr. Jackson, "was given in the time of perfect intermission, the return of paroxysm was prevented; if given under the first symptoms of a commencing paroxysm, the symptoms were suppressed, and the course of the paroxysm was so much interrupted that the disease, for the most part, lost its characteristic symptoms. If it was not given until the paroxysm was advanced in progress the symptoms of irritation, viz.: tremors, startings, spasms, and delirium, if such existed as forms of febrile action, were usually reduced in violence, sometimes entirely removed. In this case sleep, calm and refreshing, usually followed the sudden and perfect removal of pain and irritation. Vomiting, spasms, and twisting in the bowels, appearing as modes of febrile irritation, were also usually allayed by it; there was no effect from it where the vomiting or pain was connected with real inflammation or progress to disorganization." "In cases of febrile depression, deficient animation, or indifference to surrounding objects, the exhibition of eight or ten grains of cobweb was often followed by exhilaration: the eyes sparkled; the countenance assumed a temporary animation, and, though the course of the disease might not be changed, or the danger averted, more respite was obtained than is gotten from wine, opium, or anything else within my knowledge."