One other case I have had illustrative of its action in the presence of excessive quantities of uric acid in the urine: A lady, æt 76, was under my care for a very curious affection. She had considerable rheumatic muscular pains in various parts, and constant profuse perspirations day and night. Along with this she had the most abundant secretion of uric acid, which passed away with every discharge of urine. Sometimes the uric acid formed small calculi, which gave much pain in their passage down the ureter, but it generally appeared in the form of coarse sand, which formed a thick layer at the bottom of the utensil. This sand continued to pass after the cessation of the sweats and rheumatic pains, which lasted six or seven weeks. I tried various remedies--_Pulsatilla_, _Picric acid_, _Lycopodium_, etc., but without effect. At last I bethought me of Rademacher's recommendation of _Thlaspi_, and after a few doses of the 1st dilution the sand diminished very much, and, indeed, sometimes disappeared altogether, and when it did return, it was in insignificant quantity. On the whole, I think this medicine deserves a thorough and complete proving. It is evidently a powerful anti-hæmorrhagic, and its influence on the urinary organs, more particularly in bringing away and in curing excess of uric acid in the urine, is very remarkable. I have elsewhere mentioned the power of this substance to affect the secretion of uric acid, and then I have seen several cases corroborative of its medicinal virtues in this direction. One, a gentleman, æt. 57, who, in addition to other dyspeptic symptoms, had occasionally large discharges of coarse uric acid, coming away in masses the size of a good big pin's head, but curiously enough without pain. I prescribed _Thlaspi_, which he said soon stopped the uric acid. Nearly a year after this he called on me for a different affection, and informed me that the uric acid had reappeared several times in his urine, but that a few doses of _Thlaspi_ 1 stopped it, and it never came to the height it attained when I first gave it to him. A lady, nearly eighty years of age, was suffering from the pressure of a calculus in the left ureter, which I knew to be of uric acid, as she had previously passed much 'sand.' The urine showed no sand, and was very scanty. I tried several remedies, among the rest the Borocitrate of magnesia, but it was not till I gave _Thlaspi_ 1 that a great discharge of coarse brick-colored sand took place, with speedy relief to her pain. At the same time, indeed, I made her drink copiously of distilled water, which has a powerfully disintegrating effect on uric acid sometimes, but, as she had already been taking this for several days without effect, I am inclined to give the whole credit of the cure to _Thlaspi_.