REMARKS.--In looking over the above proving we find a number of illustrations of the alternate action of the drug. But perhaps what strikes the reader most forcibly is the way the symptoms follow Reuter's series. The most prominent symptoms early developed, catarrhal and gastric, have come and gone within three or four days, while those affecting the chest, heart, sensorium, eyes, brain, and nerves are more slowly developed, and are the ones that persist. Another thing to be noticed is the long duration of its action. The high-water mark in regard to its action was not reached (I mean its action on the nervous system) until nearly ten days after discontinuing to take it. It is an _antipsoric_ of remarkable power. Some skin symptoms developed by it persisted off and on for years, two or three of which I will mention. "Itching of the right popliteal space," this after continuing for eight or nine years disappeared. I think some _Sepia_ [Greek: Ip] I took had something to do with its disappearance. Another: "Itching with roughness of the skin, like eczema, above the left knee anteriorly." This still persists. I still have "Itching, with an eruption resembling at times herpes zoster below the left scapula." This is still present, although annoying. I have done nothing to cause its disappearance. In regard to _verifications_ I could report a goodly number. One of the first I ever had was a case of eczema of both hands, extending as far as the elbows. Cured in six weeks. The provings point in the direction of kidney troubles, and I have seen it speedily cause the disappearance of deposits in the urine that were giving much inconvenience. In a case of dropsy of cardiac and renal origin (albuminuria) in which there was great oedema, cured in two or three weeks. Sleeplessness, peculiar in its nature, corresponding to the proving, is relieved by it. Intercostal neuralgia, especially on left side. Anterior crural neuralgia, an aggravated case, promptly relieved. I need not say that the symptoms strongly point to rheumatism. I could say much on that part of the subject, and there is the sphere in which it has seemed to have been useful by the professional friend to whom I have furnished the medicine for trial. In a monograph by Dr. R. E. Kunge, of New York, and the writer, I ventured the prediction that _Cereus bonplandii_ would prove of value in the treatment of insanity. I send you the report of two cases. I have one other still under treatment. A patient for fourteen years in the Middletown Insane Hospital, improving, called to see Ida Reamer, a young woman of eighteen, living in New Scotland, on what is called the Heldeberg Mountain or hill, on the evening of April 19th, 1884. For some time previously she had been living with a relative in Albany, attending school and assisting in household labor. Had studied hard and probably overtaxed her strength. Her friends noticing that she was not her former self, and that though usually amiable and cheerful,