Isabella, the wife of Dr. John Graham, was born in Scotland, on the twenty-ninth of July, 1742. At the age of seventeen she became a member of the church in Paisley of which the Rev. Dr. Witherspoon, afterwards President of Princeton college, was the pastor. Dr. Graham was a physician of the same town. Her marriage took place in 1765. The next year Dr. Graham was ordered to join his regiment then stationed in Canada. After spending a few months at Montreal, he removed to Fort Niagara, where he remained in the garrison four years. Just before the Revolutionary war the sixteenth regiment of Royal Americans was ordered to the island of Antigua. Thither Dr. Graham removed with his family, and there he died in 1774. Mrs. Graham then returned to her native land. In 1789 she came to this country, and permanently settled in the city of New York. She there opened a school for young ladies, and gained a high reputation in her profession. She united with the Presbyterian church of which John Mason, D. D., was pastor, and was noted, through all the latter years of her life, for the depth of her piety and her Christian benevolence. She made it a rule to give a tenth part of her earnings to religious and charitable purposes. In 1795 she received, at one time, an advance of a thousand pounds on the sale of a lease which she held on some building lots; and not being used to such large profits, she said, on receiving the money, "Quick, quick, let me appropriate the tenth before my heart grows hard." Two years afterwards, a society was organized and chartered, for the relief of poor widows; and Mrs. Graham was appointed first directress. Each of the managers had a separate district, and she had the superintendence of the whole. A house was purchased by the society, where work was received for the employment of the widows; and a school was opened for the instruction of their children. "Besides establishing this school, Mrs. Graham selected some of the widows, best qualified for the task, and engaged them, for a small compensation, to open day schools for the instruction of the children of widows, in distant parts of the city: she also established two Sabbath schools, one of which she superintended herself, and the other she placed under the care of her daughter. Wherever she met with Christians sick and in poverty, she visited and comforted them; and in some instances opened small subscription lists to provide for their support. She attended occasionally for some years at the Alms House for the instruction of the children there, in religious knowledge: in this work she was much assisted by a humble and pious female friend, who was seldom absent from it on the Lord's day.