At the commencement of the pamphlet, the arrangement of which does not seem to us to be quite clear and easy, Dr. V. gives a sketch of the situation and localities of Leghorn. He traces the fevers of that place to putrid matters, perceptible by the sense of smell; and principally to obstructed drains. He does not give the exact degree of heat, but merely states that it was excessive, and followed by heavy rains. IV. THERAPEUTICS, MATERIA MEDICA, AND THE PRACTICE OF MEDICINE. 22. _Iodine._--In the former numbers of this journal, we offered some observations respecting the medicinal properties of iodine, intending then to present in one of our future numbers an elaborate analysis of a valuable work on this subject, by Dr. Manson, which appeared in England sometime last year.[32] Fearing, however, that the want of room and time will prevent us from fulfilling this task, as soon as soon as might be desired, we have thought that a condensed notice of its contents would be acceptable in this place. It appears that previously to the discovery of iodine as a medicinal agent, our author used the burnt sponge in bronchocele, a disease very common in the neighbourhood of Nottingham, where he practices. But when the effects of the former remedy was announced, Dr. M. prepared a tincture composed of one drachm of iodine to two ounces and a half of rectified spirit, (spec. grav. 916.) and prescribed it very extensively in doses of from 10 to 30 drops three times a day, according to the age and strength of the patient. Dr. MANSON has presented a tabular view of 116 cases of bronchocele treated by iodine, and also a detailed account of 15 more cases, with appropriate remarks. Of the former, there were, viz:-- Males--Cured, 10 Much relieved, 1 Discharged for non-attendance, 1 Improving under treatment, 3--Total 15 Females--Cured, 66 Much relieved, 9 Not relieved, 2 Discharged for non-attendance, 10 Improving under treatment, 14--101--116 Whilst using the tincture internally, Dr. MANSON occasionally had recourse externally to a liniment composed of Liniment. Sap. Comp. [Symbol: ounce]i Tinct. Iodinae, [symbol: dram]i _m._ Some patients can bear this quantity rubbed into the tumour once, and sometimes twice a day; though in some, the skin is so tender, that the liniment cannot be so frequently used. Dr. M. prefers this liniment to the common iodine ointment, as less liable to evaporation. In France, we believe Dr. RICHOND prefers rubbing in the tincture itself. The following remarks are useful: