consequence of that general languor and want of energy which too much external heat induces in the functions, particularly in that power by which the living body preserves itself from putrefaction. Now if this portion of the blood, thus altered and depraved, is readily secreted and speedily thrown out, as in _cholera morbus_, no harm befals the constitution, nor any inconvenience but what arises from the irritation of the _primæ viæ_. But this may not take place if the body should be otherwise deranged; for the removal of this noxious matter from the mass of blood depends upon a due irritability of the blood vessels, the liver, and the bowels, whereby they are stimulated to contract, and thereby expel it. According to the principle of Mr. John Hunter, (whose deep and industrious researches into the animal œconomy place him high in the list of those few on whom nature has bestowed real genius, and who are capable of adding something new to the stock of human knowledge,) there is in a state of health a relative habitude or mutual harmony existing between the solids and fluids, whereby they stimulate and produce actions in each other, in which the healthy state of the functions consists, whether employed in the formation of what is found, or the expulsion of what is noxious: so that where it happens that the solids have a morbid insensibility to the impressions of corrupted and acrimonious fluids, the retention of these adds still more to the general derangement. To illustrate this, it may be observed, that the stomach and bowels, when they are endowed, as it were, with their natural perception, immediately expel any preternatural accumulations of bile that may take place; but when they are insensible to this stimulus through disease, no effort is made to relieve nature till it is excited by medicine. The same reasoning may be applied to the various vessels and ducts. Thus when we see the liver gorged with bile, without any free excretion of it into the gall bladder, as I have sometimes found to be the case upon inspecting the body in some of the worst cases of fever, would it not appear that the gall ducts have lost that natural irritability whereby the bile is expelled? Or, in consequence of a depraved state of action, connected with febrile affection, may it not happen that the absorbents, which, in their natural state, only absorb particular substances, and in a given quantity, will suffer a change in this natural action, and absorb whatever happens to be applied to their orifices? In case of jaundice, the bile, which is perhaps not at all absorbed in a state of health, is taken up in large quantities, and mingled with the mass of blood, which proves a seasonable relief in the state of accumulation and distension occasioned by the obstruction. This may happen in cases of fever, not indeed as a relief to nature, but from a depraved state of irritability in the lymphatics, induced by disease. Though no increased quantity