Now we can often observe that when one of the lymphoid structures is changed, the others may follow; and this shows that just as the ductless glands are in close relation to one another, so also the ductless glands and the lymphoid structures stand in close mutual connection, as we have mentioned in previous works, emphasizing the fact that the tonsils are often much enlarged in myxœdema, Graves’s disease, acromegaly, diabetes, etc. In addition to these intimate relations there are also other causes arising from the tonsils that affect the appendix. Such is the case when the tonsils are inflamed and infectious matter arising therefrom reaches the intestines. The cause of appendicitis from such a source has been confirmed by the bacteriological examinations of Professors Lanz and Tavel. Indeed, clinically, we can often see that appendicitis has been, in quite a number of cases, the result of previous tonsillitis, this in turn often being caused by the secretion from the inflamed posterior part of the nose coming in contact with the tonsils, as has been previously stated. Very frequently such a condition exists in conjunction with adenoid vegetations, and this explains the error into which Delcour has fallen in his book on the relation of adenoid vegetations to appendicitis, in which he attributes the immediate cause of the latter to a state induced by an insufficiency of the thyroid gland. We can often observe that adenoid vegetations can exist with a good thyroid and _vice versâ_, although we cannot deny the fact that in children with thyroid insufficiency adenoid vegetations are frequent. It is very probable that the first mentioned causes of appendicitis and the last named often go together, the one assisting and developing the other. The unfavorable anatomical position and constipation, together, offer a very favorable soil in which, through bacterial co-operation after tonsillitis, influenza, or other infectious diseases, this much dreaded disease can develop. By a slight operation life is often saved. The pity is that such aid is often invoked too late. ------------------------------------------------------------------------ CHAPTER XXI. ON THE ELIMINATION OF TOXIC PRODUCTS THROUGH THE KIDNEYS. IN the course of this work we have frequently insisted on the fact that we are being continually poisoned during the processes of life, either by poisons coming from without into our body through food or drink, or by toxic substances being formed in our body through defective metabolism. We have a series of glands with internal secretions which have properties antagonistic to these poisons, the most important of such glands being the thyroid, parathyroid glands, adrenals and the liver, which act by destroying these injurious products.