Pelikan: “Gerichlach Med. Untersuchenger über das Skopzentham in Russland,” Giessen, 1876. Besides provoking senility at an early period, castration or a degenerated condition of the sexual glands, especially in women, is able to produce alterations in organs, which are of great importance to the vitality of individuals, and to a long life, such as the heart, stomach, intestines, and liver. Experienced authorities have noted heart troubles in dysmenorrhœa and amenorrhœa, and also neurosis of the heart with long, lasting alterations of the female sexual glands. Professor Kisch[100] also noted tachycardia in such conditions. Professor Landau[101] has very often observed a degeneration of the heart after myoma of the uterus. Lehman and Strassmann, in the Berlin Charité, have seen such a degenerated condition of the heart in 44 per cent. of patients with myomas of the uterus. Footnote 100: Kisch: “Das Geschlestrlehen der Frau,” second edition, Vienna, 1908. Footnote 101: Quoted after Kisch. It has been shown by experiments that there is a close relation between the condition of the ovaries and the heart. Professor Hegar[102] has demonstrated that castration, or simple tugging of the ovaries, is able to produce a diminution of the heart beats, or even a stoppage of the heart. Lucas Championnière has also noted the same after a tearing of the ovaries, and Mariagalli and Negri have also noted tachycardia after laparotomy. Footnote 102: Quoted after Kisch; as also other authors on the relation between heart and stomach, and the ovaries. Very important also are the relations between the ovaries and the digestive organs. Kretschy observed, in a case of fistula in the stomach, that alterations of the female sexual organs regularly produced also alterations of the digestive functions; for instance, during menstruation there is always an increased flow of hydrochloric acid. The same has been found by Fleischer, who noted during this period a sluggishness in digestion, which improved after menstruation. Tanecki found dyspeptic troubles in cases of retroflexion of the uterus, and Eisenheart has observed the disappearance of acute gastric troubles after a cure of retroflexion. P. Muller also declares that there are intimate relations between the sexual glands and the digestive organs. He also observed dyspeptic troubles during menstruation; and Professor Leyden has noted neuralgia and hyperæsthesia of the stomach in young girls after menstrual troubles. Habitual chronic constipation, which is so frequent after a degenerated condition of the sexual glands, points to the existence of close relations between these organs and the intestines.