Soon after the introduction of chloroform, I administered it to a gentleman, aged about 55, whilst a fatty tumour was removed from the nape of the neck. It did not turn out as fatty tumours usually do, but required to be dissected out. The patient had taken a meal before the operation, and vomited freely afterwards. On his visit the next morning, the surgeon thought his patient going on well. Vomiting returned, however, and the patient became affected with partial stupor and delirium, which his friends attributed to the chloroform. He became covered with an eruption of erysipelas over a great part of the body, had a very rapid pulse with great depression, and died on the fifth day. An examination after death showed that there had been diffuse cellular inflammation around the seat of the operation. A surgeon who assisted at the operation on the above patient, and also at the post-mortem examination, removed an encysted tumour from the scalp of an old lady the day following the latter event. This operation was performed without chloroform, but the patient was attacked with erysipelas and diffuse cellular information, and died in three or four days. _Faintness and Depression._ Although chloroform acts as a stimulant to the circulation, increasing the force and frequency of the pulse whilst it is being inhaled, it is occasionally followed by a feeling of faintness, especially if the patient remains in the sitting posture. At one period in the history of medical opinion, it would have been said that the depression was a consequence of the previous excitement. The facts, however, would not agree with such a doctrine. The subjects who are most stimulated by chloroform are the strong and robust, and they do not suffer from depression afterwards; whilst the feeble and debilitated, who are most liable to subsequent depression, are but little stimulated by it at the time of inhaling. Some amount of faintness and depression usually accompanies the sickness caused by chloroform, and is in fact a consequence of it, being, like the sickness, most frequent after a full meal. This depression is usually relieved by vomiting. I have met with a few cases in which there has been more decided faintness, and once or twice absolute syncope after chloroform, which was not attributable to loss of blood. In these cases, however, the patients were in the sitting posture, and they recovered from the syncope immediately, on being placed horizontally. The patients most subject to faintness after chloroform are those who are subject to this affection at other times, being often persons in a state of anæmia, or having the symptoms of fatty degeneration of the heart. Faintness is, however, very much more rare after operations with chloroform than without it. The only cases in which I have seen it follow the use of chloroform in the horizontal position, and where there was no considerable loss of blood, have been two or three of operations on the