On chloroform and other anæsthetics: their action and administrationSnow, John
History
On chloroform and other anæsthetics: their action and administration
Snow, John
Anesthetics; Chloroform; Snow, John, 1813-1858
It is, however, only by a knowledge of the different modes in which
chloroform is capable of causing death, that the exact nature of the
accidents from this agent can be understood, together with the means of
preventing them, and the reason why they are usually irremediable when
they happen. If animals are kept for a very long time under the deep
influence of chloroform, they become ultimately exhausted, the
circulation and respiration are gradually weakened, and cease nearly
together. Such a mode of death from this agent is never likely to occur
to the human subject, and therefore need not engage our further
attention. The following experiments illustrate the different modes of
dying, when death is caused more suddenly by this agent.[57]
_Experiment 23._ A young but full grown cat was placed in a glass jar,
of the capacity of 1,600 cubic inches, and a fluid drachm of chloroform
was introduced, by a portion at a time, through a tube in the cover of
the jar. As twenty-five minims of chloroform produce twenty-six cubic
inches of vapour, the atmosphere which the cat had to breathe contained
nearly four per cent. of vapour, and the jar was moved about, to ensure
the uniform mixture of the vapour with the air. In five minutes, the cat
became insensible, and lay breathing naturally. In about ten minutes
more, the breathing became very feeble, and it ceased altogether in
about another minute, or sixteen minutes after the cat commenced to
breathe the chloroform. It was immediately taken out and laid on a
table, and the stethoscope was applied to the chest. The heart could be
heard beating distinctly at first, but the pulsations became slower and
feebler, and in about a minute they could be no longer heard. Just at
this time, however, the cat took a gasping inspiration, and immediately
the heart was heard to beat in a most rapid manner. The gasps were
repeated, and the action of the heart became less rapid, but stronger.
In a little time, both the breathing and the action of the heart became
natural, the cat remaining, however, insensible for some minutes.
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